Ici D1542

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581077

CAS#: 147332-48-7

Description: Ici D1542 is also known as ZD1542, Ici D1542 is a potent thromboxane A2 synthase inhibitor and receptor antagonist in vitro. ZD1542 is a drug that exhibits both potent,selective TXS inhibition and TXA2 receptor antagonism.

Chemical Structure

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Ici D1542
CAS# 147332-48-7
Instruction

Theoretical Analysis

MedKoo Cat#: 581077
Name: Ici D1542
CAS#: 147332-48-7
Chemical Formula: C25H30N2O7
Exact Mass: 470.21
Molecular Weight: 470.520
Elemental Analysis: C, 63.82; H, 6.43; N, 5.95; O, 23.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ici D1542; Ici-D1542; ZD 1542; D1542; D 1542;

IUPAC/Chemical Name: 6-(2-(1-Methyl-1-(2-nitro-4-tolyloxy)ethyl)-4-(3-pyridyl)-1,3-dioxan-5-yl)hex-4-enoic acid

InChi Key: VGBBXLWOWUXXFE-SNAWJCMRSA-N

InChi Code: InChI=1S/C25H30N2O7/c1-17-11-12-21(20(14-17)27(30)31)34-25(2,3)24-32-16-19(8-5-4-6-10-22(28)29)23(33-24)18-9-7-13-26-15-18/h4-5,7,9,11-15,19,23-24H,6,8,10,16H2,1-3H3,(H,28,29)/b5-4+

SMILES Code: O=C(O)CC/C=C/CC1C(C2=CC=CN=C2)OC(C(OC3=CC=C(C)C=C3[N+]([O-])=O)(C)C)OC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 470.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: McAuliffe SJ, Moors JA, Snow HM, Wayne M, Jessup R. Redirection of arachidonic acid metabolism by ICI D1542: effects on thrombus formation in the coronary artery of the anaesthetized dog. Br J Pharmacol. 1993 Apr;108(4):901-6. PubMed PMID: 8485629; PubMed Central PMCID: PMC1908127.

2: Crankshaw D. Effects of the isoprostane, 8-epi-prostaglandin F2 alpha, on the contractility of the human myometrium in vitro. Eur J Pharmacol. 1995 Oct 16;285(2):151-8. PubMed PMID: 8566133.

3: McAuliffe SJ, Moors JA, Jones HB. Comparative effects of anti-platelet agents as adjuncts to tissue plasminogen activator in a dog model of occlusive coronary thrombosis. Br J Pharmacol. 1994 May;112(1):272-6. PubMed PMID: 8032650; PubMed Central PMCID: PMC1910308.

4: Dines KC, Cotter MA, Cameron NE. Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. Prostaglandins Leukot Essent Fatty Acids. 1996 Sep;55(3):159-65. PubMed PMID: 8931113.

5: Brownlie RP, Brownrigg NJ, Butcher HM, Garcia R, Jessup R, Lee VJ, Tunstall S, Wayne MG. ZD1542, a potent thromboxane A2 synthase inhibitor and receptor antagonist in vitro. Br J Pharmacol. 1993 Dec;110(4):1600-6. PubMed PMID: 8306107; PubMed Central PMCID: PMC2175849.