Paramethasone
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MedKoo CAT#: 584336

CAS#: 53-33-8

Description: Paramethasone is a glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than Hydrocortisone with supplementary Fludrocortisone.


Price and Availability

Size Price Shipping out time Quantity
2mg USD 345 2 Weeks
25mg USD 1650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

Paramethasone, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584336
Name: Paramethasone
CAS#: 53-33-8
Chemical Formula: C22H29FO5
Exact Mass: 392.1999
Molecular Weight: 392.4674
Elemental Analysis: C, 67.33; H, 7.45; F, 4.84; O, 20.38


Synonym: Paramethasone; CS 1483

IUPAC/Chemical Name: Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-

InChi Key: MKPDWECBUAZOHP-AFYJWTTESA-N

InChi Code: InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

SMILES Code: C[C@@]12[C@](C(CO)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: López-Serrano MC, Moreno-Ancillo A, Contreras J, Ortega N, Cabañas R, Barranco P, Muñoz-Pereira M. Two cases of specific adverse reactions to systemic corticosteroids. J Investig Allergol Clin Immunol. 1996 Sep-Oct;6(5):324-7. PubMed PMID: 8959545.

2: Friedrich L, Wuppermann D, Zimmermann F. [Effect of high dosis of D-penicillamine and paramethasone on mechanical properties of rat connective tissue (author's transl)]. Arch Dermatol Forsch. 1975;252(2):161-6. German. PubMed PMID: 1147696.

3: Cortés-Gallegos V, Carranco A, Sojo I, Alonso R, Valenzuela-Duriet P. Effect of paramethasone acetate upon estrogen action. Fertil Steril. 1982 Mar;37(3):402-5. PubMed PMID: 7060790.

4: Montoro J, Valero A, Serra-Baldrich E, Amat P, Lluch M, Malet A. Anaphylaxis to paramethasone with tolerance to other corticosteroids. Allergy. 2000 Feb;55(2):197-8. PubMed PMID: 10726740.

5: Cortés-Gallegos V, Alonso R, Castañeda G, Sojo I, Carranco A, Cervantes C, Parra A. Paramethasone acetate (PA): corticosteroid potency vs hypothalamic pituitary-gonadal axis. J Steroid Biochem. 1984 Jan;20(1):353-6. PubMed PMID: 6423900.

6: Cortés-Gallegos V, Alonso-Uriarte ME, Said LE, Cervantes C, Parra A. Effect of paramethasone acetate on women with secondary amenorrhea: a preliminary report. Fertil Steril. 1978 Apr;29(4):402-6. PubMed PMID: 77230.

7: Rovira E, García-Escrig M, Catalá J, García J. [Chronic adhesive arachnoiditis following epidural paramethasone]. Rev Neurol. 1997 Dec;25(148):2067-8. Spanish. PubMed PMID: 9528075.

8: JAUREGUIGUTIERREZ R, TREVINODELAPENA E. [PARAMETHASONE. CLINICAL EVALUATION IN 20 PATIENTS WITH RHEUMATOID ARTHRITIS TREATED FROM 6 TO 34 MONTHS WITHOUT INTERRUPTION]. Medicina (Mex). 1964 Feb 10;44:49-55. Spanish. PubMed PMID: 14143135.

9: Gum OB. A controlled study of two preparations, paramethasone, propoxyphene, and aspirin and propoxyphene and aspirin in the treatment of arthritis. Am J Med Sci. 1966 Mar;251(3):328-32. PubMed PMID: 5324359.

10: MATHIES H, RASPE J. [COMPARATIVE CLINICAL STUDIES WITH PARAMETHASONE AND PREDNISONE]. Arzneimittelforschung. 1963 Dec;13:1058-63. German. PubMed PMID: 14208677.

11: Wasek Z, Plusa T. [Clinical evaluation of triamcinolone and paramethasone in the treatment of chronic asthma]. Pneumonol Pol. 1976;44(1):49-53. Polish. PubMed PMID: 940780.

12: Montes Eeyes JS. [Treatment of sport injuries by using paramethasone acetate]. Rev Esp Reum Enferm Osteoartic. 1976;19(2):203-24. Spanish. PubMed PMID: 959639.

13: Bonomo I, Reis SS, Vieira FJ, Toledo AH, Barreto AC, Pascoal WR, Costa RM. [Clinical trial of paramethasone by intra-articular administration]. Hospital (Rio J). 1971 Jan;79(1):95-9. Portuguese. PubMed PMID: 5316658.

14: MATHIES H. [PARAMETHASONE IN THE THERAPY OF CHRONIC POLYARTHRITIS]. Med Monatsschr. 1964 Oct;18:465-7. German. PubMed PMID: 14334934.

15: Nakamura H, Matsushita K, Hata M, Sakaguchi H. Less toxic corticosteroid therapy in canine renal allografts. Keio J Med. 1978 Apr;27(1):15-21. PubMed PMID: 216844.

16: FURUKAWA W, TAKEUCHI T. [CLINICAL TRIAL OF PARAMETHASONE ACETATE IN PEDIATRICS]. Chiryo. 1964;46:780-4. Japanese. PubMed PMID: 14148039.

17: MIZRAJI M. [PARAMETHASONE IN THE TREATMENT OF SOME RHEUMATIC DISEASES]. Rev Esp Reum Enferm Osteoartic. 1963 Apr;10:122-6. Spanish. PubMed PMID: 14076943.

18: ROBLESGIL J, KATONA G. [4 YEARS' EXPERIENCE WITH PARAMETHASONE IN THE TREATMENT OF RHEUMATOID ARTHRITIS]. Arch Interam Rheumatol. 1964 Mar;7:104-19. Spanish. PubMed PMID: 14154181.

19: Desbrosses J. [Injectable paramethasone acetate in surgical practice]. Lyon Med. 1970 Nov 29;224(39):741-3. French. PubMed PMID: 5485437.

20: Davies GE, Thompson A. Effects of corticosteroid treatment and inflammation on the cellular content of blood and exudate in mice. J Pathol. 1975 Jan;115(1):17-26. PubMed PMID: 125317.