Beaucage reagent
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MedKoo CAT#: 562119

CAS#: 66304-01-6

Description: Beaucage reagent is a DNA cleavage reagent.

Chemical Structure

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Beaucage reagent
CAS# 66304-01-6
Instruction

Theoretical Analysis

MedKoo Cat#: 562119
Name: Beaucage reagent
CAS#: 66304-01-6
Chemical Formula: C7H4O3S2
Exact Mass: 199.96
Molecular Weight: 200.220
Elemental Analysis: C, 41.99; H, 2.01; O, 23.97; S, 32.02

Price and Availability

Size Price Availability Quantity
1g USD 205 2 weeks
5g USD 500 2 weeks
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Synonym: Beaucage reagent;

IUPAC/Chemical Name: 3H-Benzo[c][1,2]dithiol-3-one 1,1-dioxide

InChi Key: JUDOLRSMWHVKGX-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H4O3S2/c8-7-5-3-1-2-4-6(5)12(9,10)11-7/h1-4H

SMILES Code: O=C1C2=CC=CC=C2S(S1)(=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 200.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1: Manoharan M, Lu Y, Casper MD, Just G. Allyl group as a protecting group for internucleotide phosphate and thiophosphate linkages in oligonucleotide synthesis: facile oxidation and deprotection conditions. Org Lett. 2000 Feb 10;2(3):243-6. PubMed PMID: 10814292.

2: Xu Q, Musier-Forsyth K, Hammer RP, Barany G. Use of 1,2,4-dithiazolidine-3,5-dione (DtsNH) and 3-ethoxy-1,2,4-dithiazoline-5-one (EDITH) for synthesis of phosphorothioate-containing oligodeoxyribonucleotides. Nucleic Acids Res. 1996 May 1;24(9):1602-7. PubMed PMID: 8649975; PubMed Central PMCID: PMC145860.

3: Lesiak K, Khamnei S, Torrence PF. 2',5'-Oligoadenylate:antisense chimeras--synthesis and properties. Bioconjug Chem. 1993 Nov-Dec;4(6):467-72. PubMed PMID: 8305516.