Zanamivir hydrate
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MedKoo CAT#: 581075

CAS#: 551942-41-7 (hydrate)

Description: Zanamivir hydrate is neuraminidase inhibitors (NAIs) and is used worldwide for treatment and prophylaxis of influenza caused by influenza A and B viruses.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 400 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-12. Prices are subject to change without notice.

Zanamivir hydrate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 581075
Name: Zanamivir hydrate
CAS#: 551942-41-7 (hydrate)
Chemical Formula: C12H22N4O8
Exact Mass: 350.1438
Molecular Weight: 350.33
Elemental Analysis: C, 41.14; H, 6.33; N, 15.99; O, 36.53


Related CAS #: 139110-80-8 (free base)   551942-41-7 (hydrate)  

Synonym: Zanamivir hydrate; D01937; J1.917.534K;

IUPAC/Chemical Name: (+)-(4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,2R)-1,2,3- trihydroxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid hydrate

InChi Key: OELRRAURPSTFEX-VCFRRRQNSA-N

InChi Code: InChI=1S/C12H20N4O7.H2O/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17;/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16);1H2/t5-,6+,8+,9+,10+;/m0./s1

SMILES Code: O=C(C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1)O.[H]O[H]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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Zanamivir for influenza in adults and children: systematic review of clinical
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PMC3981976.

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10.1016/j.antiviral.2014.02.017. Epub 2014 Feb 28. PubMed PMID: 24583158.

3: Chan-Tack KM, Kim C, Moruf A, Birnkrant DB. Clinical experience with
intravenous zanamivir under an Emergency IND program in the United States
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7: Sato M, Honzumi K, Sato T, Hashimoto K, Watanabe M, Miyazaki K, Kawasaki Y,
Hosoya M. Sequential influenza B viral load and susceptibility in children
treated with oseltamivir and zanamivir. Pediatr Infect Dis J. 2014
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8: Lou Y, Gan J, Peppercorn A, Gould E, Weller S, Piscitelli SC, Patel P. Effect
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Peppercorn AF. Safety and pharmacokinetics of intravenous zanamivir treatment in
hospitalized adults with influenza: an open-label, multicenter, single-arm, phase
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10: Tian J, Zhong J, Li Y, Ma D. Organocatalytic and scalable synthesis of the
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12: Weight AK, Belser JA, Tumpey TM, Chen J, Klibanov AM. Zanamivir conjugated to
poly-L-glutamine is much more active against influenza viruses in mice and
ferrets than the drug itself. Pharm Res. 2014 Feb;31(2):466-74. doi:
10.1007/s11095-013-1175-4. Epub 2013 Sep 25. PubMed PMID: 24065587; PubMed
Central PMCID: PMC3964776.

13: Shi LL, Cao Y, Zhu XY, Cui JH, Cao QR. Optimization of process variables of
zanamivir-loaded solid lipid nanoparticles and the prediction of their cellular
transport in Caco-2 cell model. Int J Pharm. 2015 Jan 15;478(1):60-9. doi:
10.1016/j.ijpharm.2014.11.017. Epub 2014 Nov 12. PubMed PMID: 25448568.

14: Weller S, Jones LS, Lou Y, Peppercorn A, Ng-Cashin J. Pharmacokinetics of
zanamivir following intravenous administration to subjects with and without renal
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15: Zonja B, Gonçalves C, Pérez S, Delgado A, Petrovic M, Alpendurada MF, Barceló
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N-Hydroxyguanidine-Based Prodrug Approaches to Tackle Poor Oral Bioavailability.
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Reutterer B, Seifert JM, Unger H, Grassauer A, Prieschl-Grassauer E, Nakowitsch
S. The Intranasal Application of Zanamivir and Carrageenan Is Synergistically
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Zanamivir binding affinity with original and mutant influenza neuraminidase 9
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