WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 330105
CAS#: 555-45-3
Description: Trimyristin a triacylglycerol of myristic acid that is found in nutmeg. It has been used to prepare lipophilic and cationic lipophilic micro- and nanoparticles carriers loaded with proteins, peptides, and oligonucleotides.
MedKoo Cat#: 330105
Name: Trimyristin
CAS#: 555-45-3
Chemical Formula: C45H86O6
Exact Mass: 722.6424
Molecular Weight: 723.177
Elemental Analysis: C, 74.74; H, 11.99; O, 13.27
Synonym: Trimyristin; Myristic Acid Triglyceride; NSC 4062.
IUPAC/Chemical Name: propane-1,2,3-triyl tritetradecanoate
InChi Key: DUXYWXYOBMKGIN-UHFFFAOYSA-N
InChi Code: InChI=1S/C45H86O6/c1-4-7-10-13-16-19-22-25-28-31-34-37-43(46)49-40-42(51-45(48)39-36-33-30-27-24-21-18-15-12-9-6-3)41-50-44(47)38-35-32-29-26-23-20-17-14-11-8-5-2/h42H,4-41H2,1-3H3
SMILES Code: O=C(CCCCCCCCCCCCC)OCC(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 723.177 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Göke K, Roese E, Arnold A, Kuntsche J, Bunjes H. Control over Particle Size Distribution by Autoclaving Poloxamer-Stabilized Trimyristin Nanodispersions. Mol Pharm. 2016 Sep 6;13(9):3187-95. doi: 10.1021/acs.molpharmaceut.6b00395. Epub 2016 Aug 9. PubMed PMID: 27463039.
2: Gehrer S, Schmiele M, Westermann M, Steiniger F, Unruh T. Liquid crystalline phase formation in suspensions of solid trimyristin nanoparticles. J Phys Chem B. 2014 Sep 25;118(38):11387-96. doi: 10.1021/jp506787v. Epub 2014 Sep 15. PubMed PMID: 25201309.
3: Lugemwa FN. Extraction of betulin, trimyristin, eugenol and carnosic acid using water-organic solvent mixtures. Molecules. 2012 Aug 3;17(8):9274-82. doi: 10.3390/molecules17089274. PubMed PMID: 22864237.
4: Martins S, Silva AC, Ferreira DC, Souto EB. Improving oral absorption of Salmon calcitonin by trimyristin lipid nanoparticles. J Biomed Nanotechnol. 2009 Feb;5(1):76-83. PubMed PMID: 20055109.
5: Sonesson AW, Elofsson UM, Callisen TH, Brismar H. Tracking single lipase molecules on a trimyristin substrate surface using quantum dots. Langmuir. 2007 Jul 31;23(16):8352-6. Epub 2007 Jul 6. PubMed PMID: 17616159.
6: Sonesson AW, Brismar H, Callisen TH, Elofsson UM. Mobility of Thermomyces lanuginosus lipase on a trimyristin substrate surface. Langmuir. 2007 Feb 27;23(5):2706-13. Epub 2007 Jan 30. PubMed PMID: 17261037.
7: Johnson W Jr; Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate. Int J Toxicol. 2001;20 Suppl 4:61-94. Review. PubMed PMID: 11800053.
8: van Langevelde A, Peschar R, Schenk H. Structure of beta-trimyristin and beta-tristearin from high-resolution X-ray powder diffraction data. Acta Crystallogr B. 2001 Jun;57(Pt 3):372-7. Epub 2001 Jun 1. PubMed PMID: 11373397.
9: Bennett AJ, Billett MA, Salter AM, Mangiapane EH, Bruce JS, Anderton KL, Marenah CB, Lawson N, White DA. Modulation of hepatic apolipoprotein B, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor mRNA and plasma lipoprotein concentrations by defined dietary fats. Comparison of trimyristin, tripalmitin, tristearin and triolein. Biochem J. 1995 Oct 1;311 ( Pt 1):167-73. PubMed PMID: 7575449; PubMed Central PMCID: PMC1136134.
