SA-16

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562105

CAS#: 1919884-11-9

Description: SA-16 is a potent PDK1 and Aurora kinase A dual inhibitor.

Chemical Structure

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SA-16
CAS# 1919884-11-9
Instruction

Theoretical Analysis

MedKoo Cat#: 562105
Name: SA-16
CAS#: 1919884-11-9
Chemical Formula: C33H24F2N6O4
Exact Mass: 606.18
Molecular Weight: 606.580
Elemental Analysis: C, 65.34; H, 3.99; F, 6.26; N, 13.85; O, 10.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SA-16; SA 16; SA16;

IUPAC/Chemical Name: (R,Z)-N-(2-((3-((1H-Imidazol-5-yl)methylene)-2-oxoindolin-5-yl)amino)-2-oxo-1-phenylethyl)-1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

InChi Key: XCPMMIISBZJPHR-OXTLUBNBSA-N

InChi Code: InChI=1S/C33H24F2N6O4/c34-26-10-8-19(13-27(26)35)17-41-12-4-7-23(33(41)45)30(42)40-29(20-5-2-1-3-6-20)32(44)38-21-9-11-28-24(14-21)25(31(43)39-28)15-22-16-36-18-37-22/h1-16,18,29H,17H2,(H,36,37)(H,38,44)(H,39,43)(H,40,42)/b25-15-/t29-/m1/s1

SMILES Code: O=C(C1=CC=CN(CC2=CC=C(F)C(F)=C2)C1=O)N[C@H](C3=CC=CC=C3)C(NC4=CC5=C(NC(/C5=C\C6=CN=CN6)=O)C=C4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 606.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Daniele S, Sestito S, Pietrobono D, Giacomelli C, Chiellini G, Di Maio D, Marinelli L, Novellino E, Martini C, Rapposelli S. Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114. doi: 10.1021/acschemneuro.6b00251. Epub 2016 Nov 10. PubMed PMID: 27797168.

2: Giraud K, Pontin M, Sharples LD, Fletcher P, Dalgleish T, Eden A, Jenkins DP, Vuylsteke A. Use of a Structured Mirrors Intervention Does Not Reduce Delirium Incidence But May Improve Factual Memory Encoding in Cardiac Surgical ICU Patients Aged Over 70 Years: A Pilot Time-Cluster Randomized Controlled Trial. Front Aging Neurosci. 2016 Sep 28;8:228. eCollection 2016. PubMed PMID: 27733826; PubMed Central PMCID: PMC5039170.

3: Dabul AN, Kos VN, Gilmore MS, Camargo IL. Draft Genome Sequence of Methicillin-Resistant Staphylococcus aureus Strain SA16, Representative of an Endemic Clone from a Brazilian Hospital. Genome Announc. 2013 Sep 19;1(5). pii: e00754-13. doi: 10.1128/genomeA.00754-13. PubMed PMID: 24051324; PubMed Central PMCID: PMC3778207.

4: Asiegbu FO, Abu S, Stenlid J, Johansson M. Sequence polymorphism and molecular characterization of laccase genes of the conifer pathogen Heterobasidion annosum. Mycol Res. 2004 Feb;108(Pt 2):136-48. PubMed PMID: 15119350.