WNK-IN-7

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562102

CAS#: 2125724-72-1

Description: WNK-IN-7 is a potent and selectiive inhibitor of WNK1 kinase.

Chemical Structure

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WNK-IN-7
CAS# 2125724-72-1
Instruction

Theoretical Analysis

MedKoo Cat#: 562102
Name: WNK-IN-7
CAS#: 2125724-72-1
Chemical Formula: C26H29N3O
Exact Mass: 399.23
Molecular Weight: 399.530
Elemental Analysis: C, 78.16; H, 7.32; N, 10.52; O, 4.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: WNK-IN-7; WNK IN 7; WNKIN7; WNK inhibitor 7; WNK inhibitor-7;

IUPAC/Chemical Name: N-((1-(2-(3-Methoxyphenyl)-5-methylpyridin-4-yl)-1H-indol-3-yl)methyl)-2-methylpropan-1-amine

InChi Key: KRRYUYQXCUJXNA-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H29N3O/c1-18(2)14-27-16-21-17-29(25-11-6-5-10-23(21)25)26-13-24(28-15-19(26)3)20-8-7-9-22(12-20)30-4/h5-13,15,17-18,27H,14,16H2,1-4H3

SMILES Code: CC(C)CNCC1=CN(C2=CC(C3=CC=CC(OC)=C3)=NC=C2C)C4=C1C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 399.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bhuiyan MIH, Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1. PubMed PMID: 27798271; PubMed Central PMCID: PMC5536788.

2: Wang D, Zhang Y, Han J, Pan S, Xu N, Feng X, Zhuang Z, Caroti C, Zhuang J, Hoover RS, Gu D, Zeng Q, Cai H. WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway. Nephron. 2016;133(4):287-95. doi: 10.1159/000447717. Epub 2016 Jul 29. PubMed PMID: 27467688.

3: Pasham V, Rotte A, Yang W, Zelenak C, Bhandaru M, Föller M, Lang F. OSR1-sensitive regulation of Na+/H+ exchanger activity in dendritic cells. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C416-26. doi: 10.1152/ajpcell.00420.2011. Epub 2012 May 30. PubMed PMID: 22648948.

4: Cui Y, Huang Q, Auman JT, Knight B, Jin X, Blanchard KT, Chou J, Jayadev S, Paules RS. Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity. Toxicol Sci. 2011 Nov;124(1):23-34. doi: 10.1093/toxsci/kfr217. Epub 2011 Aug 24. PubMed PMID: 21865292; PubMed Central PMCID: PMC3196657.

5: Yagi YI, Abe K, Ikebukuro K, Sode K. Kinetic mechanism and inhibitor characterization of WNK1 kinase. Biochemistry. 2009 Nov 3;48(43):10255-66. doi: 10.1021/bi900666n. PubMed PMID: 19739668.

6: Jun P, Hong C, Lal A, Wong JM, McDermott MW, Bollen AW, Plass C, Held WA, Smiraglia DJ, Costello JF. Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. Neuro Oncol. 2009 Aug;11(4):414-22. doi: 10.1215/15228517-2008-096. Epub 2008 Nov 11. PubMed PMID: 19001526; PubMed Central PMCID: PMC2743221.

7: Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB. WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney Int. 2006 Jun;69(12):2162-70. Epub 2006 May 10. PubMed PMID: 16688122.

8: Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem. 2004 Feb 27;279(9):7826-31. Epub 2003 Dec 16. PubMed PMID: 14681216.