Bax-activator-106

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562077

CAS#: 1638526-94-9

Description: Bax-activator-106 is a specific Bax agonist. It acts by promoting Bax-dependent but not Bak-dependent apoptosis.


Price and Availability

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Bax-activator-106 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562077
Name: Bax-activator-106
CAS#: 1638526-94-9
Chemical Formula: C29H36N4O3
Exact Mass: 488.2787
Molecular Weight: 488.63
Elemental Analysis: C, 71.28; H, 7.43; N, 11.47; O, 9.82


Synonym: Bax-activator-106; Baxactivator106; Bax activator 106;

IUPAC/Chemical Name: (R)-(5-(3,4-dimethylbenzyl)-1-(3-methoxybenzyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)(3-hydroxypiperidin-1-yl)methanone

InChi Key: OLNVSYZSZXRLCF-XMMPIXPASA-N

InChi Code: InChI=1S/C29H36N4O3/c1-20-9-10-23(14-21(20)2)16-31-13-11-27-26(19-31)28(29(35)32-12-5-7-24(34)18-32)30-33(27)17-22-6-4-8-25(15-22)36-3/h4,6,8-10,14-15,24,34H,5,7,11-13,16-19H2,1-3H3/t24-/m1/s1

SMILES Code: O=C(C1=NN(CC2=CC=CC(OC)=C2)C3=C1CN(CC4=CC=C(C)C(C)=C4)CC3)N5C[C@H](O)CCC5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shivakumar S, Kurylowicz M, Hirmiz N, Manan Y, Friaa O, Shamas-Din A, Masoudian P, Leber B, Andrews DW, Fradin C. The proapoptotic protein tBid forms both superficially bound and membrane-inserted oligomers. Biophys J. 2014 May 20;106(10):2085-95. doi: 10.1016/j.bpj.2014.03.049. PubMed PMID: 24853737; PubMed Central PMCID: PMC4052270.

2: Pan B, Yang L, Wang J, Wang Y, Wang J, Zhou X, Yin X, Zhang Z, Zhao D. C-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis via regulating mitochondrial homeostasis. Mol Neurobiol. 2014 Apr;49(2):1102-16. doi: 10.1007/s12035-014-8646-4. Epub 2014 Feb 8. PubMed PMID: 24510275.

3: Jeong JK, Moon MH, Lee YJ, Seol JW, Park SY. Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity. Neurobiol Aging. 2013 Jan;34(1):146-56. doi: 10.1016/j.neurobiolaging.2012.04.002. Epub 2012 May 9. PubMed PMID: 22575359.

4: Sun CK, Chang CL, Lin YC, Kao YH, Chang LT, Yen CH, Shao PL, Chen CH, Leu S, Yip HK. Systemic administration of autologous adipose-derived mesenchymal stem cells alleviates hepatic ischemia-reperfusion injury in rats. Crit Care Med. 2012 Apr;40(4):1279-90. doi: 10.1097/CCM.0b013e31823dae23. PubMed PMID: 22336724.

5: Leu S, Lin YC, Yuen CM, Yen CH, Kao YH, Sun CK, Yip HK. Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. J Transl Med. 2010 Jun 28;8:63. doi: 10.1186/1479-5876-8-63. PubMed PMID: 20584315; PubMed Central PMCID: PMC2913939.