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MedKoo CAT#: 555154

CAS#: 1037826-43-9

Description: A-933548 is a potent Calpain inhibitor for the Treatment of Alzheimer's Disease. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-07. Prices are subject to change without notice.

A-933548 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555154
Name: A-933548
CAS#: 1037826-43-9
Chemical Formula: C25H21N5O3
Exact Mass: 439.1644
Molecular Weight: 439.475
Elemental Analysis: C, 68.33; H, 4.82; N, 15.94; O, 10.92

Related CAS #: 1037826-43-9   1037827-50-1 (S-isomer)   2127397-43-5 (R-isomer)    

Synonym: A-933548; A933548; A 933548;

IUPAC/Chemical Name: N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide


InChi Code: InChI=1S/C25H21N5O3/c26-23(32)22(31)21(16-17-8-3-1-4-9-17)28-25(33)19-12-7-14-27-24(19)30-15-13-20(29-30)18-10-5-2-6-11-18/h1-15,21H,16H2,(H2,26,32)(H,28,33)

SMILES Code: O=C(NC(C(C(N)=O)=O)CC1=CC=CC=C1)C2=C(N3N=C(C4=CC=CC=C4)C=C3)N=CC=C2

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Kling A, Jantos K, Mack H, Hornberger W, Drescher K, Nimmrich V, Relo A, Wicke
K, Hutchins CW, Lao Y, Marsh K, Moeller A. Discovery of Novel and Highly
Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease:
2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides. J Med Chem. 2017 Aug
24;60(16):7123-7138. doi: 10.1021/acs.jmedchem.7b00731. Epub 2017 Aug 15. PubMed
PMID: 28759231.

2. Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1′ Extension
Andreas Kling, Katja Jantos, Helmut Mack, Wilfried Hornberger, Gisela Backfisch, Yanbin Lao, Marjoleen Nijsen, Beatrice Rendenbach-Mueller, and Achim Moeller
Publication Date (Web): February 4, 2018 (Letter)
DOI: 10.1021/acsmedchemlett.7b00494