GIBH-130
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555149

CAS#: 1252608-59-5

Description: GIBH-130 is a neuroinflammation inhibitor. GIBH-130 exhibited comparable in vivo efficacy of cognitive impairment relief to donepezil and memantine respectively in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models at a substantially lower dose (0.25 mg/kg). Therefore, GIBH-130 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents.


Price and Availability

Size
Price

100mg
USD 950
1g
USD 3750
Size
Price

200mg
USD 1450
2g
USD 4850
Size
Price

500mg
USD 2150
5g
USD 6950

GIBH-130, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555149
Name: GIBH-130
CAS#: 1252608-59-5
Chemical Formula: C20H20N6O
Exact Mass: 360.1699
Molecular Weight: 360.421
Elemental Analysis: C, 66.65; H, 5.59; N, 23.32; O, 4.44


Synonym: GIBH-130; GIBH 130; GIBH130.

IUPAC/Chemical Name: (4-methyl-6-phenylpyridazin-3-yl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone

InChi Key: ZTJHTEHADIHZJS-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H20N6O/c1-15-14-17(16-6-3-2-4-7-16)23-24-18(15)19(27)25-10-12-26(13-11-25)20-21-8-5-9-22-20/h2-9,14H,10-13H2,1H3

SMILES Code: O=C(C1=NN=C(C2=CC=CC=C2)C=C1C)N3CCN(C4=NC=CC=N4)CC3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Zhou W, Zhong G, Fu S, Xie H, Chi T, Li L, Rao X, Zeng S, Xu D, Wang H, Sheng
G, Ji X, Liu X, Ji X, Wu D, Zou L, Tortorella M, Zhang K, Hu W. Microglia-Based
Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective
in Alzheimer's Disease Models. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507.
Epub 2016 Sep 2. PubMed PMID: 27504670.