WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555149
Description: GIBH-130 is a neuroinflammation inhibitor. GIBH-130 exhibited comparable in vivo efficacy of cognitive impairment relief to donepezil and memantine respectively in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models at a substantially lower dose (0.25 mg/kg). Therefore, GIBH-130 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents.
MedKoo Cat#: 555149
Chemical Formula: C20H20N6O
Exact Mass: 360.1699
Molecular Weight: 360.421
Elemental Analysis: C, 66.65; H, 5.59; N, 23.32; O, 4.44
Synonym: GIBH-130; GIBH 130; GIBH130.
IUPAC/Chemical Name: (4-methyl-6-phenylpyridazin-3-yl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
InChi Key: ZTJHTEHADIHZJS-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H20N6O/c1-15-14-17(16-6-3-2-4-7-16)23-24-18(15)19(27)25-10-12-26(13-11-25)20-21-8-5-9-22-20/h2-9,14H,10-13H2,1H3
SMILES Code: O=C(C1=NN=C(C2=CC=CC=C2)C=C1C)N3CCN(C4=NC=CC=N4)CC3
1: Zhou W, Zhong G, Fu S, Xie H, Chi T, Li L, Rao X, Zeng S, Xu D, Wang H, Sheng
G, Ji X, Liu X, Ji X, Wu D, Zou L, Tortorella M, Zhang K, Hu W. Microglia-Based
Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective
in Alzheimer's Disease Models. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507.
Epub 2016 Sep 2. PubMed PMID: 27504670.