WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555145
Description: MDK7229, also known as MD2-IN-1 is a MD2 (Myeloid differentiation protein 2) inhibitor. MDK7229 has CAS#111797-22-9. For easy communication, we use its last 4 digit of CAS for name. MDK7229 locked the LPS-induced activation of TLR4/MD2 -downstream pro-inflammatory MAPKs/NF-κB signaling pathways. In a rat model with ALI induced by intracheal LPS instillation, administration MDK7229 exhibited significant protective effect against ALI, accompanied by the inhibition of TLR4/MD2 complex formation in lung tissues.
MedKoo Cat#: 555145
Chemical Formula: C20H22O6
Exact Mass: 358.1416
Molecular Weight: 358.39
Elemental Analysis: C, 67.03; H, 6.19; O, 26.78
Synonym: MD2-IN-1; MDK7229; MDK 7229; MDK 7229.
IUPAC/Chemical Name: (E)-1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
InChi Key: ZKYRYELHPFTZTI-SOFGYWHQSA-N
InChi Code: InChI=1S/C20H22O6/c1-22-16-9-7-14(12-17(16)23-2)15(21)8-6-13-10-18(24-3)20(26-5)19(11-13)25-4/h6-12H,1-5H3/b8-6+
SMILES Code: COC1=C(OC)C(OC)=CC(/C=C/C(C2=CC=C(OC)C(OC)=C2)=O)=C1
1: Zhang Y, Wu J, Ying S, Chen G, Wu B, Xu T, Liu Z, Liu X, Huang L, Shan X, Dai
Y, Liang G. Discovery of new MD2 inhibitor from chalcone derivatives with
anti-inflammatory effects in LPS-induced acute lung injury. Sci Rep. 2016 Apr
27;6:25130. doi: 10.1038/srep25130. PubMed PMID: 27118147; PubMed Central PMCID: