MDK7229
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555145

CAS#: 111797-22-9

Description: MDK7229, also known as MD2-IN-1 is a MD2 (Myeloid differentiation protein 2) inhibitor. MDK7229 has CAS#111797-22-9. For easy communication, we use its last 4 digit of CAS for name. MDK7229 locked the LPS-induced activation of TLR4/MD2 -downstream pro-inflammatory MAPKs/NF-κB signaling pathways. In a rat model with ALI induced by intracheal LPS instillation, administration MDK7229 exhibited significant protective effect against ALI, accompanied by the inhibition of TLR4/MD2 complex formation in lung tissues.


Price and Availability

Size
Price

100mg
USD 950
1g
USD 3650
Size
Price

200mg
USD 1650
2g
USD 4850
Size
Price

500mg
USD 2250
5g
USD 7650

MDK7229, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555145
Name: MDK7229
CAS#: 111797-22-9
Chemical Formula: C20H22O6
Exact Mass: 358.1416
Molecular Weight: 358.39
Elemental Analysis: C, 67.03; H, 6.19; O, 26.78


Synonym: MD2-IN-1; MDK7229; MDK 7229; MDK 7229.

IUPAC/Chemical Name: (E)-1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

InChi Key: ZKYRYELHPFTZTI-SOFGYWHQSA-N

InChi Code: InChI=1S/C20H22O6/c1-22-16-9-7-14(12-17(16)23-2)15(21)8-6-13-10-18(24-3)20(26-5)19(11-13)25-4/h6-12H,1-5H3/b8-6+

SMILES Code: COC1=C(OC)C(OC)=CC(/C=C/C(C2=CC=C(OC)C(OC)=C2)=O)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Zhang Y, Wu J, Ying S, Chen G, Wu B, Xu T, Liu Z, Liu X, Huang L, Shan X, Dai
Y, Liang G. Discovery of new MD2 inhibitor from chalcone derivatives with
anti-inflammatory effects in LPS-induced acute lung injury. Sci Rep. 2016 Apr
27;6:25130. doi: 10.1038/srep25130. PubMed PMID: 27118147; PubMed Central PMCID:
PMC4846832.