GA11

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562054

CAS#: 851053-64-0

Description: GA11 inhibitor of ALDH1. It also shows anti-GBM effects in vitro and in vivo.


Price and Availability

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Price

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GA11 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562054
Name: GA11
CAS#: 851053-64-0
Chemical Formula: C19H14N2
Exact Mass: 270.1157
Molecular Weight: 270.33
Elemental Analysis: C, 84.42; H, 5.22; N, 10.36


Synonym: GA11; GA-11; GA 11;

IUPAC/Chemical Name: 2,6-Diphenyl-imidazo[1,2-a]pyridine

InChi Key: LETMYYZWCFHZLY-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H14N2/c1-3-7-15(8-4-1)17-11-12-19-20-18(14-21(19)13-17)16-9-5-2-6-10-16/h1-14H

SMILES Code: C12=NC(C3=CC=CC=C3)=CN1C=C(C4=CC=CC=C4)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Institute for Quality and Efficiency in Health Care. Stem Cell Transplantation for Multiple Myeloma -- Update [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2015 Mar 30. Available from http://www.ncbi.nlm.nih.gov/books/NBK385769/ PubMed PMID: 28609086.

2: Cheng P, Wang J, Waghmare I, Sartini S, Coviello V, Zhang Z, Kim SH, Mohyeldin A, Pavlyukov MS, Minata M, Valentim CL, Chhipa RR, Bhat KP, Dasgupta B, La Motta C, Kango-Singh M, Nakano I. FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells. Cancer Res. 2016 Dec 15;76(24):7219-7230. Epub 2016 Aug 28. PubMed PMID: 27569208; PubMed Central PMCID: PMC5161538.

3: Briceño G, Schalchli H, Rubilar O, Tortella GR, Mutis A, Benimeli CS, Palma G, Diez MC. Increased diazinon hydrolysis to 2-isopropyl-6-methyl-4-pyrimidinol in liquid medium by a specific Streptomyces mixed culture. Chemosphere. 2016 Aug;156:195-203. doi: 10.1016/j.chemosphere.2016.04.118. Epub 2016 May 10. PubMed PMID: 27176942.

4: Steenbergen KG, Gaston N. First-principles melting of gallium clusters down to nine atoms: structural and electronic contributions to melting. Phys Chem Chem Phys. 2013 Oct 7;15(37):15325-32. doi: 10.1039/c3cp51690c. PubMed PMID: 23764996.

5: Föllner CG, Madkour M, Mayer F, Babel W, Steinbüchel A. Analysis of the PHA granule-associated proteins GA20 and GA11 in Methylobacterium extorquens and Methylobacterium rhodesianum. J Basic Microbiol. 1997;37(1):11-21. PubMed PMID: 9090123.

6: Saing KM, Orii H, Tanaka Y, Yanagisawa K, Miura A, Ikeda H. Formation of deletion in Escherichia coli between direct repeats located in the long inverted repeats of a cellular slime mold plasmid: participation of DNA gyrase. Mol Gen Genet. 1988 Sep;214(1):1-5. PubMed PMID: 2852300.