WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407880
Description: OSS-128167, also known as SIRT6-IN-1, is a potent and selective SIRT 6 inhibitor.
MedKoo Cat#: 407880
Chemical Formula: C19H14N2O6
Exact Mass: 366.0852
Molecular Weight: 366.329
Elemental Analysis: C, 62.30; H, 3.85; N, 7.65; O, 26.20
Synonym: OSS-128167; OSS 128167; OSS128167; SIRT6-IN-1
IUPAC/Chemical Name: 5-(3-(furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid
InChi Key: HTJWLEGCECXGSQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)
SMILES Code: C1=CC(NC(=O)C2=CC=CO2)=CC(C(=O)NC2=CC=C(O)C(C(O)=O)=C2)=C1
In cancer and aging-associated pathways, SIRT6 is crucial since it prevents genomic instability, maintains telomere integrity, and regulates metabolic homeostasis and DNA repair. SIRT6 can be considered a double-edged sword in cancer because of its dual role of both tumor suppressor and oncogene. In healthy conditions, SIRT6 either acts as a gatekeeper of DNA repair mechanisms or regulates cell survival and proliferation. Following the DNA damage, SIRT6 triggers the apoptotic process, hence it is down-regulated in several cancers. However, in other cancers, it is up-regulated, corroborating the idea that it can also act as oncogene.