OSS-128167
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407880

CAS#: 887686-02-4

Description: OSS-128167, also known as SIRT6-IN-1, is a potent and selective SIRT 6 inhibitor.


Price and Availability

Size
Price

100mg
USD 1150
1g
USD 3450
Size
Price

200mg
USD 1450
2g
USD 4650
Size
Price

500mg
USD 2250
5g
USD 8450

OSS-128167, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407880
Name: OSS-128167
CAS#: 887686-02-4
Chemical Formula: C19H14N2O6
Exact Mass: 366.0852
Molecular Weight: 366.329
Elemental Analysis: C, 62.30; H, 3.85; N, 7.65; O, 26.20


Synonym: OSS-128167; OSS 128167; OSS128167; SIRT6-IN-1

IUPAC/Chemical Name: 5-(3-(furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid

InChi Key: HTJWLEGCECXGSQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)

SMILES Code: C1=CC(NC(=O)C2=CC=CO2)=CC(C(=O)NC2=CC=C(O)C(C(O)=O)=C2)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

In cancer and aging-associated pathways, SIRT6 is crucial since it prevents genomic instability, maintains telomere integrity, and regulates metabolic homeostasis and DNA repair. SIRT6 can be considered a double-edged sword in cancer because of its dual role of both tumor suppressor and oncogene. In healthy conditions, SIRT6 either acts as a gatekeeper of DNA repair mechanisms or regulates cell survival and proliferation. Following the DNA damage, SIRT6 triggers the apoptotic process, hence it is down-regulated in several cancers. However, in other cancers, it is up-regulated, corroborating the idea that it can also act as oncogene.