ML365
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MedKoo CAT#: 555142

CAS#: 947914-18-3

Description: ML365 is a potent and selective K2P3.1 TASK-1 channel blocker. ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM). Based on potency differences, it possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related, two-pore domain potassium channel, TASK3. ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). Based on these criteria, ML365 is a best-in-class probe and is a useful pharmacological probe for in vitro studies of TASK1 function and in further studies aimed at developing therapeutic intervention.


Price and Availability

Size
Price

50mg
USD 550
500mg
USD 1950
5g
USD 6950
Size
Price

100mg
USD 850
1g
USD 3250
Size
Price

200mg
USD 1250
2g
USD 4850

ML365, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555142
Name: ML365
CAS#: 947914-18-3
Chemical Formula: C22H20N2O3
Exact Mass: 360.1474
Molecular Weight: 360.413
Elemental Analysis: C, 73.32; H, 5.59; N, 7.77; O, 13.32


Synonym: ML365; ML-365; ML 365;

IUPAC/Chemical Name: 2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

InChi Key: UTAJHKSGYJSZBR-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)

SMILES Code: O=C(NC1=CC=CC(NC(C2=CC=CC(C)=C2)=O)=C1)C3=CC=CC=C3OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Skarsfeldt MA, Jepps TA, Bomholtz SH, Abildgaard L, Sørensen US, Gregers E,
Svendsen JH, Diness JG, Grunnet M, Schmitt N, Olesen SP, Bentzen BH. pH-dependent
inhibition of K₂P3.1 prolongs atrial refractoriness in whole hearts. Pflugers
Arch. 2016 Apr;468(4):643-54. doi: 10.1007/s00424-015-1779-0. Epub 2016 Jan 5.
PubMed PMID: 26729267.

2: Zou B, Flaherty DP, Simpson DS, Maki BE, Miller MR, Shi J, Wu M, McManus OB,
Golden JE, Aubé J, Li M. ML365: Development of Bis-Amides as Selective Inhibitors
of the KCNK3/TASK1 Two Pore Potassium Channel. 2013 Apr 15 [updated 2013 Nov 14].
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD):
National Center for Biotechnology Information (US); 2010-. Available from
http://www.ncbi.nlm.nih.gov/books/NBK179826/
PubMed PMID: 24479195.