ML335
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MedKoo CAT#: 555141

CAS#: 825658-06-8

Description: ML335 is a potent and selective TREK-1/2 Activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.


Price and Availability

Size
Price

50mg
USD 550
500mg
USD 1950
5g
USD 6850
Size
Price

100mg
USD 850
1g
USD 2950
Size
Price

200mg
USD 1250
2g
USD 3850

ML335, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555141
Name: ML335
CAS#: 825658-06-8
Chemical Formula: C15H14Cl2N2O3S
Exact Mass: 372.0102
Molecular Weight: 373.248
Elemental Analysis: C, 48.27; H, 3.78; Cl, 19.00; N, 7.51; O, 12.86; S, 8.59


Synonym: ML335; ML-335; ML 335; TREK-1/2 Activator;

IUPAC/Chemical Name: N-[(2,4-Dichlorophenyl)methyl]-4-(methanesulfonamido)benzamide

InChi Key: RDFIQTZRJRVFHK-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H14Cl2N2O3S/c1-23(21,22)19-13-6-3-10(4-7-13)15(20)18-9-11-2-5-12(16)8-14(11)17/h2-8,19H,9H2,1H3,(H,18,20)

SMILES Code: O=C(NCC1=CC=C(Cl)C=C1Cl)C2=CC=C(NS(=O)(C)=O)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Lolicato M, Arrigoni C, Mori T, Sekioka Y, Bryant C, Clark KA, Minor DL Jr.
K(2P)2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding
site. Nature. 2017 Jul 20;547(7663):364-368. doi: 10.1038/nature22988. Epub 2017
Jul 10. PubMed PMID: 28693035; PubMed Central PMCID: PMC5778891.

2: Pinello C, Guerrero M, Eberhart C, Volmar CH, Saldanha SA, Cayanan C, Urbano
M, Brown SJ, Ferguson J, Gomes I, Devi LA, Roberts E, Hodder P, Rosen H.
Characterization of an agonist probe for opioid receptor mu 1 (OPRM1)-opioid
receptor delta 1 (OPRD1) heterodimerization. 2012 Dec 17 [updated 2013 Apr 5].
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD):
National Center for Biotechnology Information (US); 2010-. Available from
http://www.ncbi.nlm.nih.gov/books/NBK148496/
PubMed PMID: 23833799.