WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555140
Description: KKL-10 is an antimicrobial agent. KKL-10 exhibited exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis in vitro and during ex vivo infection. Addition of KKL-10 to macrophages or liver cells at any time after infection by F. tularensis prevented further bacterial proliferation. When macrophages were stimulated with the proinflammatory cytokine gamma interferon before being infected by F. tularensis, addition of KKL-10 reduced intracellular bacteria by >99%, indicating that the combination of cytokine-induced stress and a nonfunctional ribosome rescue pathway is fatal to F. tularensis. KKL-10 is a good lead compound for antibiotic development.
MedKoo Cat#: 555140
Chemical Formula: C14H10BrN3O2S
Exact Mass: 362.9677
Molecular Weight: 364.217
Elemental Analysis: C, 46.17; H, 2.77; Br, 21.94; N, 11.54; O, 8.79; S, 8.80
Synonym: KKL-10; KKL 10; KKL10.
IUPAC/Chemical Name: 5-bromo-N-(5-(p-tolyl)-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide
InChi Key: QKSDWSBGDVYRKQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H10BrN3O2S/c1-8-2-4-9(5-3-8)13-17-18-14(20-13)16-12(19)10-6-7-11(15)21-10/h2-7H,1H3,(H,16,18,19)
SMILES Code: O=C(C1=CC=C(Br)S1)NC2=NN=C(C3=CC=C(C)C=C3)O2
Bacteria require at least one pathway to rescue ribosomes stalled at the ends of mRNAs. The primary pathway for ribosome rescue is trans-translation, which is conserved in >99% of sequenced bacterial genomes. Some species also have backup systems, such as ArfA or ArfB, which can rescue ribosomes in the absence of sufficient trans-translation activity. Small-molecule inhibitors of ribosome rescue have broad-spectrum antimicrobial activity against bacteria grown in liquid culture.