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MedKoo CAT#: 341023

CAS#: 72402-20-1

Description: Z-10-Hydroxyamitriptyline

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-30. Prices are subject to change without notice.

Z-10-Hydroxyamitriptyline is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 341023
Name: Z-10-Hydroxyamitriptyline
CAS#: 72402-20-1
Chemical Formula: C20H23NO
Exact Mass: 293.178
Molecular Weight: 293.41
Elemental Analysis: C, 81.87; H, 7.90; N, 4.77; O, 5.45

Synonym: Z-10-Hydroxyamitriptyline

IUPAC/Chemical Name: 5H-Dibenzo(a,d)cyclohepten-10-ol, 5-(3-(dimethylamino)propylidene)-10,11-dihydro-, (Z)-


InChi Code: InChI=1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12-

SMILES Code: CN(C)CC\C=C/1\c2ccccc2CC(O)c3ccccc13

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Shimoda K, Yasuda S, Morita S, Shibasaki M, Someya T, Bertilsson L, Takahashi S. Significance of monitoring plasma levels of amitriptyline, and its hydroxylated and desmethylated metabolites in prediction of the clinical outcome of depressive state. Psychiatry Clin Neurosci. 1997 Feb;51(1):35-41. PubMed PMID: 9076859.

2: Ulrich S, Isensee T, Pester U. Simultaneous determination of amitriptyline, nortriptyline and four hydroxylated metabolites in serum by capillary gas-liquid chromatography with nitrogen-phosphorus-selective detection. J Chromatogr B Biomed Appl. 1996 Oct 11;685(1):81-9. PubMed PMID: 8930756.

3: Breyer-Pfaff U, Becher B, Nusser E, Nill K, Baier-Weber B, Zaunbrecher D, Wachsmuth H, Prox A. Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine. Xenobiotica. 1990 Jul;20(7):727-38. PubMed PMID: 2238706.

4: Nusser E, Nill K, Breyer-Pfaff U. Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine. J Chromatogr. 1990 Jun 8;528(1):163-71. PubMed PMID: 2384550.

5: Edelbroek PM, Zitman FG, Schreuder JN, Rooymans HG, de Wolff FA. Amitriptyline metabolism in relation to antidepressive effect. Clin Pharmacol Ther. 1984 Apr;35(4):467-73. PubMed PMID: 6705444.