Z-160 hydrochloride

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MedKoo CAT#: 341019

CAS#: 41332-36-9

Description: Z-160 hydrochloride is a biochemical.


Price and Availability

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Pricing updated 2020-08-14. Prices are subject to change without notice.

Z-160 hydrochloride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 341019
Name: Z-160 hydrochloride
CAS#: 41332-36-9
Chemical Formula: C32H33ClN2O
Exact Mass: 496.2281
Molecular Weight: 497.079
Elemental Analysis: C, 77.32; H, 6.69; Cl, 7.13; N, 5.64; O, 3.22


Synonym: Z-160 hydrochloride;

IUPAC/Chemical Name: 1-(Diphenylmethyl)-4-(3,3-diphenylpropanoyl)piperazine hydrochloride

InChi Key: ZUKCTHFFBLZBGR-UHFFFAOYSA-N

InChi Code: InChI=1S/C32H32N2O.ClH/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29;/h1-20,30,32H,21-25H2;1H

SMILES Code: Cl.O=C(CC(c1ccccc1)c2ccccc2)N3CCN(CC3)C(c4ccccc4)c5ccccc5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Gabriele M, Puccini P, Lucchi M, Vizziello A, Gervasi PG, Longo V. Presence and inter-individual variability of carboxylesterases (CES1 and CES2) in human lung. Biochem Pharmacol. 2018 Jan 29;150:64-71. doi: 10.1016/j.bcp.2018.01.028. [Epub ahead of print] PubMed PMID: 29407485.

2: Freire Petrovick G, Breitkreutz J. Spheronization of solid lipid extrudates: Elucidation of spheroid formation mechanism. Eur J Pharm Biopharm. 2018 Jan 30. pii: S0939-6411(17)31034-2. doi: 10.1016/j.ejpb.2018.01.017. [Epub ahead of print] PubMed PMID: 29407224.

3: Limon D, Fabrega MJ, Calpena AC, Badía J, Baldoma L, Pérez-García L. Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases. Bioconjug Chem. 2018 Feb 6. doi: 10.1021/acs.bioconjchem.7b00717. [Epub ahead of

print] PubMed PMID: 29406699.

4: Sachett A, Bevilaqua F, Chitolina R, Garbinato C, Gasparetto H, Dal Magro J, Conterato GM, Siebel AM. Ractopamine hydrochloride induces behavioral alterations and oxidative status imbalance in zebrafish. J Toxicol Environ Health A. 2018 Feb 6:1-8. doi: 10.1080/15287394.2018.1434848. [Epub ahead of print] PubMed PMID: 29405861.

5: Kumar N, Devineni SR, Gajjala PR, Dubey SK, Kumar P. Synthesis, isolation, identification and characterization of new process-related impurity in isoproterenol hydrochloride by HPLC, LC/ESI-MS and NMR. J Pharm Anal. 2017 Dec;7(6):394-400. doi: 10.1016/j.jpha.2017.05.002. Epub 2017 May 10. PubMed PMID: 29404065; PubMed Central PMCID: PMC5790752.

6: Byadagi K, Meti M, Nandibewoor S, Chimatadar S. Investigation of binding behaviour of procainamide hydrochloride with human serum albumin using synchronous, 3D fluorescence and circular dichroism. J Pharm Anal. 2017 Apr;7(2):103-109. doi: 10.1016/j.jpha.2016.07.004. Epub 2016 Dec 9. PubMed PMID:

29404024; PubMed Central PMCID: PMC5686859.

7: Yang Y, Zhao L, Xiao L, Liang Y, Wang C, Fu X, Zhu X, Yuan S, Zhu J, Zhu X, Liu Y, Li J, Luo J, Liu F, Sun L. Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome. Kidney Blood Press Res. 2018 Jan 24;43(1):68-79. doi: 10.1159/000486911. [Epub ahead of print] PubMed PMID: 29402844.

8: Kim MJ, An HJ, Kim DH, Lee B, Lee HJ, Ullah S, Kim SJ, Jeong HO, Moon KM, Lee

EK, Yang J, Akter J, Chun P, Moon HR, Chung HY. Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice.

Bioorg Med Chem Lett. 2018 Jan 16. pii: S0960-894X(18)30031-3. doi: 10.1016/j.bmcl.2018.01.021. [Epub ahead of print] PubMed PMID: 29402742.

9: Pillai VS, Kundargi RR, Edathadathil F, Nair S, Thilak J, Mathew RA, Xavier T, Shenoy P, Menon KN. Identification of prolargin expression in articular cartilage and its significance in rheumatoid arthritis pathology. Int J Biol Macromol. 2018 Feb 1. pii: S0141-8130(17)33779-0. doi: 10.1016/j.ijbiomac.2018.01.141. [Epub ahead of print] PubMed PMID: 29402456.

10: Afify EAMR, Elsayed I, Gad MK, Mohamed MI, Afify AEMR. Enhancement of pharmacokinetic and pharmacological behavior of ocular dorzolamide after factorial optimization of self-assembled nanostructures. PLoS One. 2018 Feb 5;13(2):e0191415. doi: 10.1371/journal.pone.0191415. eCollection 2018. PubMed PMID: 29401498.

11: Danielson TA, Bowler BE. Helical Propensity Affects the Conformational Properties of the Denatured State of Cytochrome c'. Biophys J. 2018 Jan 23;114(2):311-322. doi: 10.1016/j.bpj.2017.11.3744. PubMed PMID: 29401429.

12: Sun P, Zhang Z, Luo H, Zhang P, Qin Y, Guo ZX. Synthesis, crystal structure and photophysical properties of 1,4-bis(1,3-diazaazulen-2-yl)benzene: a new π building block. Acta Crystallogr C Struct Chem. 2018 Feb 1;74(Pt 2):171-176. doi: 10.1107/S2053229617018459. Epub 2018 Jan 17. PubMed PMID: 29400332.

13: Mondal S, Samajdar RN, Mukherjee S, Bhattacharyya AJ, Bagchi B. Unique Features of Metformin: A Combined Experimental, Theoretical and Simulation Study

of its Structure, Dynamics and Interaction Energetics with DNA Grooves. J Phys Chem B. 2018 Feb 3. doi: 10.1021/acs.jpcb.7b11928. [Epub ahead of print] PubMed PMID: 29397734.

14: Okubo K, Uchida E, Terahara T, Akiyama K, Kobayashi S, Tanaka Y. Efficacy and safety of emedastine patch, a novel transdermal drug delivery system for allergic rhinitis: Phase III, multicenter, randomized, double-blinded, placebo-controlled, parallel-group comparative study in patients with seasonal allergic rhinitis. Allergol Int. 2018 Jan 29. pii: S1323-8930(17)30189-2. doi: 10.1016/j.alit.2017.12.005. [Epub ahead of print] PubMed PMID: 29395965.

15: Tsukamoto T, Takahama M, Kodai S, Kanazawa A, Hori T, Kaizaki R, Takatsuka S, Komatsu R. [Long-Term Survival after Multidisciplinary Treatment for Resected Pancreatic Adenocarcinoma with Recurrence of Pulmonary Metastases - A Case Report]. Gan To Kagaku Ryoho. 2017 Nov;44(12):1883-1885. Japanese. PubMed PMID: 29394808.

16: Budsberg SC, Torres BT, Kleine SA, Sandberg GS, Berjeski AK. Lack of effectiveness of tramadol hydrochloride for the treatment of pain and joint dysfunction in dogs with chronic osteoarthritis. J Am Vet Med Assoc. 2018 Feb 15;252(4):427-432. doi: 10.2460/javma.252.4.427. PubMed PMID: 29393744.

17: Fu S, Jin L, Gong T, Pan S, Zheng S, Zhang X, Yang T, Sun Y, Wang Y, Guo J, Hui B, Zhang X. Effect of sinomenine hydrochloride on radiosensitivity of esophageal squamous cell carcinoma cells. Oncol Rep. 2018 Jan 22. doi: 10.3892/or.2018.6228. [Epub ahead of print] PubMed PMID: 29393484.

18: Liu X, Pang F, Ge J. Synthesis of N-doped Mesoporous Carbon Nanorods through

Nano-confined Reaction: High Performance Catalyst Support for Hydrogenation of Phenol Derivatives. Chem Asian J. 2018 Feb 2. doi: 10.1002/asia.201800112. [Epub

ahead of print] PubMed PMID: 29392862.

19: Kozono H, Yoshitani H, Nakano R. Post-marketing surveillance study of the safety and efficacy of nalfurafine hydrochloride (Remitch(®) capsules 2.5 μg) in

3,762 hemodialysis patients with intractable pruritus. Int J Nephrol Renovasc Dis. 2018 Jan 15;11:9-24. doi: 10.2147/IJNRD.S145720. eCollection 2018. PubMed PMID: 29391822; PubMed Central PMCID: PMC5774492.

20: Tian S, Li J, Tao Q, Zhao Y, Lv Z, Yang F, Duan H, Chen Y, Zhou Q, Hou D. Controlled drug delivery for glaucoma therapy using montmorillonite/Eudragit microspheres as an ion-exchange carrier. Int J Nanomedicine. 2018 Jan 12;13:415-428. doi: 10.2147/IJN.S146346. eCollection 2018. PubMed PMID: 29391798; PubMed Central PMCID: PMC5769559.