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MedKoo CAT#: 562002

CAS#: 1222810-74-3

Description: VU591 is the first reported selective, small-molecule ROMK inhibitor. It inhibits potassium transport in isolated perfused rat collecting duct tubules with no effect on sodium transport.

Price and Availability

Size Price Shipping out time Quantity
5mg USD 250 2 Weeks
25mg USD 640 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-20. Prices are subject to change without notice.

VU591, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 562002
Name: VU591
CAS#: 1222810-74-3
Chemical Formula: C16H12N6O5
Exact Mass: 368.0869
Molecular Weight: 368.3
Elemental Analysis: C, 52.18; H, 3.28; N, 22.82; O, 21.72

Synonym: VU591; VU-591; VU 591;

IUPAC/Chemical Name: 2,2'-(oxybis(methylene))bis(5-nitro-1H-benzo[d]imidazole)


InChi Code: InChI=1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)

SMILES Code: O=[N+](C1=CC2=C(C=C1)NC(COCC3=NC(C=C([N+]([O-])=O)C=C4)=C4N3)=N2)[O-]

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Horng JL, Yu LL, Liu ST, Chen PY, Lin LY. Potassium Regulation in Medaka (Oryzias latipes) Larvae Acclimated to Fresh Water: Passive Uptake and Active Secretion by the Skin Cells. Sci Rep. 2017 Nov 24;7(1):16215. doi: 10.1038/s41598-017-16381-7. PubMed PMID: 29176723; PubMed Central PMCID: PMC5701230.

2: Kharade SV, Flores D, Lindsley CW, Satlin LM, Denton JS. ROMK inhibitor actions in the nephron probed with diuretics. Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F732-F737. doi: 10.1152/ajprenal.00423.2015. Epub 2015 Dec 9. PubMed PMID: 26661652; PubMed Central PMCID: PMC4835929.

3: Swale DR, Sheehan JH, Banerjee S, Husni AS, Nguyen TT, Meiler J, Denton JS. Computational and functional analyses of a small-molecule binding site in ROMK. Biophys J. 2015 Mar 10;108(5):1094-103. doi: 10.1016/j.bpj.2015.01.022. PubMed PMID: 25762321; PubMed Central PMCID: PMC4375722.

4: Bhave G, Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, Denton JS. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. doi: 10.1124/mol.110.066928. Epub 2010 Oct 6. PubMed PMID: 20926757; PubMed Central PMCID: PMC3014278.