Btm 1042

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MedKoo CAT#: 584286

CAS#: 72293-40-4

Description: Btm 1042 is an antispasmodic drug that has been found to depress twitch responses in the ileum of guinea pig.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-04-07. Prices are subject to change without notice.

Btm 1042 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584286
Name: Btm 1042
CAS#: 72293-40-4
Chemical Formula: C21H27Cl2N3OS
Exact Mass: 439.1252
Molecular Weight: 440.427
Elemental Analysis: C, 57.27; H, 6.18; Cl, 16.10; N, 9.54; O, 3.63; S, 7.28


Synonym: Btm 1042; Btm1042; Btm-1042

IUPAC/Chemical Name: 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-((4-methyl-1-piperazinyl)methyl)-2-phenyl-, dihydrochloride, cis-(-)-

InChi Key: YRHGKQWXSOSAQX-RHXOVYDGSA-N

InChi Code: InChI=1S/C21H25N3OS.2ClH/c1-23-11-13-24(14-12-23)15-17-20(16-7-3-2-4-8-16)26-19-10-6-5-9-18(19)22-21(17)25;;/h2-10,17,20H,11-15H2,1H3,(H,22,25);2*1H/t17-,20+;;/m0../s1

SMILES Code: O=C1[C@@H](CN2CCN(C)CC2)[C@@H](C3=CC=CC=C3)SC4=CC=CC=C4N1.[H]Cl.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Noronha-Blob L, Sturm BL, Lowe VC, Jackson KN, Kachur JF. In vitro and in vivo antimuscarinic effects of (-)cis 2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5 benzothiazepin-4-(5H)one HCl (BTM-1086) in guinea pig peripheral tissues. Life Sci. 1990;46(17):1223-31. PubMed PMID: 2338887.

2: Takayanagi I, Nakazo K, Kizawa Y. Possible mechanisms of a new type of antispasmodic drug, BTM-1042(cis-(--)-2,3-dihydro-3-(4-methyl-piperazinyl)methyl-2-phenyl-1,5-benzoth iazepin-4(5H)-one dihydrochloride). Jpn J Pharmacol. 1980 Oct;30(5):647-54. PubMed PMID: 7206371.

3: Yamamoto H, Nakamura Y, Nagasaka M, Asai H. Specificity in the pharmacological actions of optical isomers of cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one (BTM). Chem Pharm Bull (Tokyo). 1987 Aug;35(8):3419-24. PubMed PMID: 3427721.

4: Asano T, Okumura T, Hirano K, Adachi T, Sugiura M. Competitive enzyme immunoassay for anti-ulcer agent, (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one hydrochloride (BTM-1086). Chem Pharm Bull (Tokyo). 1986 Oct;34(10):4238-43. PubMed PMID: 3549012.

5: Ohno S, Izumi K, Mizukoshi K, Kato K, Hori M. Synthesis of a new potent anti-ulcer and gastric secretory inhibiting agent, (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiazepin-4(5 H)-one hydrochloride (BTM-1086), and related compounds. Chem Pharm Bull (Tokyo). 1983 May;31(5):1780-3. PubMed PMID: 6616728.

6: Yamamoto H, Asai H. Effects of (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl- 1,5-benzothiaze pin-4-(5H)-one hydrochloride (BTM-1086) on ulceration, gastric secretion and mucosal blood flow in experimental animals. Chem Pharm Bull (Tokyo). 1986 Sep;34(9):3844-53. PubMed PMID: 3815606.

7: Eltze M, Boer R, Mutschler E, Lambrecht G. Affinity profiles of BTM-1086 and BTM-1041 at muscarinic receptor subtypes and at H1- and alpha 1-receptors. Eur J Pharmacol. 1989 Nov 7;170(3):225-34. PubMed PMID: 2575995.

8: Yamamoto H, Nakamura Y, Kunoh Y, Ichihara K, Nagasaka M, Asai H. Antiulcer effect of (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl) -2-phenyl-1,5-benzothiazepin-4-(5H)-one hydrochloride (BTM-1086) in experimental animals. Jpn J Pharmacol. 1986 Jul;41(3):283-92. PubMed PMID: 3761747.

9: Takayanagi I, Konno F, Akaike M, Nibori Y, Yamura S. cis(-)-2,3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one monohydrochloride and its butylbromide as M1-receptor antagonists. Gen Pharmacol. 1987;18(1):91-3. PubMed PMID: 3557056.

10: Murakami H, Ishikawa T, Watanabe H. Acetylcholine release elicited by electrical stimulation and its sites of action in smooth muscle of Mytilus. Comp Biochem Physiol C. 1984;77(2):273-7. PubMed PMID: 6144427.

11: Kromer W, Baron E, Boer R, Eltze M. Telenzepine inhibits electrically-stimulated, acetylcholine plus histamine-mediated acid secretion in the mouse isolated stomach by blockade of M1 muscarine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1991 Jan;343(1):7-13. PubMed PMID: 2030745.

12: Okumura T, Asano T, Adachi T, Hirano K. Enzyme immunoassay for the drug of anti-ulcer using avidin-biotin system. Chem Pharm Bull (Tokyo). 1991 Jul;39(7):1779-81. PubMed PMID: 1777930.