Btg 502

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MedKoo CAT#: 584285

CAS#: 99083-11-1

Description: Btg 502 activates sodium channel & inhibits batrachotoxinin A-20-alpha-benzoate binding.


Price and Availability

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Pricing updated 2020-03-30. Prices are subject to change without notice.

Btg 502 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584285
Name: Btg 502
CAS#: 99083-11-1
Chemical Formula: C21H24BrNO
Exact Mass: 385.1041
Molecular Weight: 386.333
Elemental Analysis: C, 65.29; H, 6.26; Br, 20.68; N, 3.63; O, 4.14


Synonym: Btg 502; Btg-502; Btg502

IUPAC/Chemical Name: 2,4-Hexadienamide, 6-(5-bromo-2-naphthalenyl)-N-(1,2-dimethylpropyl)-, (E,E)-

InChi Key: FVMPXCCSVGCCRV-LJIKRCSCSA-N

InChi Code: InChI=1S/C21H24BrNO/c1-15(2)16(3)23-21(24)11-6-4-5-8-17-12-13-19-18(14-17)9-7-10-20(19)22/h4-7,9-16H,8H2,1-3H3,(H,23,24)/b5-4+,11-6+

SMILES Code: O=C(NC(C)C(C)C)/C=C/C=C/CC1=CC=C2C(Br)=CC=CC2=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Du Y, Khambay B, Dong K. An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. Insect Biochem Mol Biol. 2011 Jul;41(7):446-50. doi: 10.1016/j.ibmb.2011.03.005. Epub 2011 Mar 21. PubMed PMID: 21426938; PubMed Central PMCID: PMC3118982.

2: Du Y, Garden D, Khambay B, Zhorov BS, Dong K. Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels. Mol Pharmacol. 2011 Sep;80(3):426-33. doi: 10.1124/mol.111.072504. Epub 2011 Jun 16. PubMed PMID: 21680776; PubMed Central PMCID: PMC3164329.

3: Ottea JA, Payne GT, Bloomquist JR, Soderlund DM. Activation of sodium channels and inhibition of [3H]batrachotoxinin A-20-alpha-benzoate binding by an N-alkylamide neurotoxin. Mol Pharmacol. 1989 Aug;36(2):280-4. PubMed PMID: 2549384.