Viminol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341004

CAS#: 21363-18-8

Description: Viminol (marketed under the brandname Dividol) is an opioid analgesic developed by a team at the drug company Zambon in the 1960s. Viminol is based on the α-pyrryl-2-aminoethanol structure, unlike any other class of opioids.


Price and Availability

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Viminol is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 341004
Name: Viminol
CAS#: 21363-18-8
Chemical Formula: C21H31ClN2O
Exact Mass: 362.2125
Molecular Weight: 362.942
Elemental Analysis: C, 69.50; H, 8.61; Cl, 9.77; N, 7.72; O, 4.41


Synonym: Viminol; Z424.

IUPAC/Chemical Name: 1-(o-Chlorobenzyl)-alpha-((di-sec-butylamino)methyl)pyrrole-2-methanol

InChi Key: ZILPIBYANAFGMS-FIKGOQFSSA-N

InChi Code: InChI=1S/C21H31ClN2O/c1-5-16(3)24(17(4)6-2)15-21(25)20-12-9-13-23(20)14-18-10-7-8-11-19(18)22/h7-13,16-17,21,25H,5-6,14-15H2,1-4H3/t16-,17-,21-/m0/s1

SMILES Code: n1(c(ccc1)[C@@H](O)CN([C@@H](C)CC)[C@@H](C)CC)Cc1ccccc1Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Shu YJ, Bao RF, Jiang L, Wang Z, Wang XA, Zhang F, Liang HB, Li HF, Ye YY, Xiang SS, Weng H, Wu XS, Li ML, Hu YP, Lu W, Zhang YJ, Zhu J, Dong P, Liu YB. MicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway. Cell Death Differ. 2017 Mar;24(3):445-457. doi: 10.1038/cdd.2016.146. Epub 2017 Jan 6. PubMed PMID: 28060377; PubMed Central PMCID: PMC5344207.

2: Irwin RS, Curley FJ, Pratter MR. The effects of drugs on cough. Eur J Respir Dis Suppl. 1987;153:173-81. Review. PubMed PMID: 3322860.

3: Cinelli M, Costa V, Ventresca GP, Lodola E. Viminol R2 analgesic activity in patients with postoperative pain: comparison with pentazocine. Int J Clin Pharmacol Ther Toxicol. 1986 May;24(5):232-5. PubMed PMID: 3525423.

4: Shook JE, Kallman MJ, Dewey WL. The discriminative stimulus properties of the R2 isomer of viminol. Pharmacol Biochem Behav. 1984 Jan;20(1):59-62. PubMed PMID: 6546450.

5: Contri AM. [Chromatographic separation of diastereoisomers of aminoalcohol salts and their densitometric determination]. Farmaco Prat. 1981 Apr;36(4):215-22. Italian. PubMed PMID: 6894429.

6: Moroni M, Cavalli G, Lodola E. Viminol analgesic activity in elderly patients with chronic pain: a controlled evaluation, using self-rating questionnaires. Int J Clin Pharmacol Biopharm. 1978 Nov;16(11):513-5. PubMed PMID: 365795.

7: Machì A, Orzalesi L. [Blood gas analysis in patients with chronic bronchopneumopathy treated with viminol]. Minerva Anestesiol. 1978 Jun;44(6):453-6. Italian. PubMed PMID: 581699.

8: Chiarino D, Della Bella D, Jommi G, Veneziani C. Stereochemistry of viminol, a novel central analgesic. Arzneimittelforschung. 1978;28(9):1554-61. PubMed PMID: 38816.

9: Neto JM, Murad JE, Monteiro SS. Psychopharmacological properties of the viminol-p-hydroxybenzoate. Rev Bras Pesqui Med Biol. 1977 Dec;10(6):361-8. PubMed PMID: 609773.

10: Sabot G, Bagnato A, Frigerio G. Controlled evaluation of the antitussive activity of viminol p-hydroxybenzoate. Int J Clin Pharmacol Biopharm. 1977 Apr;15(4):181-3. PubMed PMID: 323163.

11: Di Matteo S, Frigerio G. [Controlled research on the use of viminol in preparation for gastroscopic studies]. Clin Ter. 1976 Dec 31;79(6):563-70. Italian. PubMed PMID: 795601.

12: Zsilla G, Cheney DL, Racagni G, Costa E. Correlation between analgesia and the decrease of acetylcholine turnover rate in cortex and hippocampus elicited by morphine, meperidine, viminol R2 and azidomorphine. J Pharmacol Exp Ther. 1976 Dec;199(3):662-8. PubMed PMID: 1036502.

13: Bella DD, Benelli G, Sassi A. Absolute configuration and biological activity of viminol stereoisomers. Pharmacol Res Commun. 1976 Apr;8(2):111-26. PubMed PMID: 1037482.

14: Bonfitto M, Bella DD, Santini V. Study of the action of some centrally acting drugs on the EEG and on a conditioned avoidance reflex in the rabbit. Arch Int Pharmacodyn Ther. 1975 Sep;217(1):131-9. PubMed PMID: 1242625.

15: Carenzi A, Guidotti A, Revuelta A, Costa E. Molecular mechanisms in the actions of morphine and viminol (R2) on rat striatum. J Pharmacol Exp Ther. 1975 Aug;194(2):311-8. PubMed PMID: 239224.

16: Della Bella D, Benelli G, Besson JM. Viminol stereoisomers and lamina V interneurons activity: preliminary results. Life Sci. 1975 Jul 1;17(1):73-4. PubMed PMID: 1173677.

17: Sacco S, Vespa N, Damonte G. [Controlled observations on the use of viminol in the treatment of the painful-apprehensive states in dental practice]. Riv Ital Stomatol. 1974 Jul-Sep;29(7-9):353-60. Italian. PubMed PMID: 4620801.

18: Frigerio G. [Viminol in the treatment of pain. Double-blind, controlled, multicentric trial]. Minerva Med. 1974 Feb 17;65(12):687-703. Italian. PubMed PMID: 4819404.

19: Babbini M, Gaiardi M, Bartoletti M. Some behavioral and EEG effects of a new analgesic agent (viminol) in comparison with morphine in rats. Eur J Pharmacol. 1973 Aug;23(2):137-46. PubMed PMID: 4739057.

20: Cameron BD, Chasseaud LF, Hardy G, Lewis JD, Saggers VH, Sword IP. The synthesis and metabolic fate of 14 C-viminol, a new analgesic, in the rat and the dog. Arzneimittelforschung. 1973 May;23(5):708-12. PubMed PMID: 4197003.