WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 527690
CAS#: 1043924-66-8
Description: p18SMI-22 is a novel INK4C inhibitor, specifically blocking the bioactivity of p18 protein.
MedKoo Cat#: 527690
Name: p18SMI-22
CAS#: 1043924-66-8
Chemical Formula: C17H18N2O5S
Exact Mass: 362.0936
Molecular Weight: 362.4
Elemental Analysis: C, 56.34; H, 5.01; N, 7.73; O, 22.07; S, 8.85
This product is not in stock, which may be available by custom synthesis.
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Synonym: p18SMI22; p18SMI 22; p18SMI-22
IUPAC/Chemical Name: Methyl (R)-(4-Acetylamino-benzenesulfonylamino)-phenyl-acetate
InChi Key: YUIQPNUBSVAFPL-MRXNPFEDSA-N
InChi Code: InChI=1S/C17H18N2O5S/c1-12(20)18-14-8-10-15(11-9-14)25(22,23)19-16(17(21)24-2)13-6-4-3-5-7-13/h3-11,16,19H,1-2H3,(H,18,20)/t16-/m1/s1
SMILES Code: O=C(OC)[C@H](NS(=O)(C1=CC=C(NC(C)=O)C=C1)=O)C2=CC=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 362.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Ardenne M, Reitnauer PG. [Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a N-(2-cyanoethylene)-urea. Novel prophylactic possibilities]. Arzneimittelforschung. 1975 Sep;25(9):1369-79. German. PubMed PMID: 22.
