BRL 55834

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584269

CAS#: 131899-25-7

Description: BRL 55834 is a potassium channel activator that has shown to relax airways and vasculature in vivo.

Chemical Structure

img
BRL 55834
CAS# 131899-25-7
Instruction

Theoretical Analysis

MedKoo Cat#: 584269
Name: BRL 55834
CAS#: 131899-25-7
Chemical Formula: C18H20F5NO3
Exact Mass: 393.14
Molecular Weight: 393.354
Elemental Analysis: C, 54.96; H, 5.13; F, 24.15; N, 3.56; O, 12.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BRL 55834; BRL55834; BRL-55834

IUPAC/Chemical Name: 2-Piperidinone, 1-(3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(pentafluoroethyl)-2H-1-benzopyran-4-yl)-, (3S-trans)-

InChi Key: ZSUFQZNGDIXQAD-CABCVRRESA-N

InChi Code: InChI=1S/C18H20F5NO3/c1-16(2)15(26)14(24-8-4-3-5-13(24)25)11-9-10(6-7-12(11)27-16)17(19,20)18(21,22)23/h6-7,9,14-15,26H,3-5,8H2,1-2H3/t14-,15+/m1/s1

SMILES Code: O=C1N([C@H]2[C@H](O)C(C)(C)OC3=CC=C(C(F)(F)C(F)(F)F)C=C23)CCCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 393.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Bowring NE, Arch JR, Buckle DR, Taylor JF. Comparison of the airways relaxant and hypotensive potencies of the potassium channel activators BRL 55834 and levcromakalim (BRL 38227) in vivo in guinea-pigs and rats. Br J Pharmacol. 1993 Aug;109(4):1133-9. PubMed PMID: 8401925; PubMed Central PMCID: PMC2175747.

2: Arch JR, Bowring NE, Buckle DR. Evaluation of the novel potassium channel activator BRL 55834 as an inhaled bronchodilator in guinea-pigs and rats: comparison with levcromakalim and salbutamol. Pulm Pharmacol. 1994 Apr;7(2):121-8. PubMed PMID: 8081072.

3: Shi Z, Yan Z, Luo W. [Antigen-induced airway leakage in asthmatic guinea-pigs and the effects of BRL 55834]. Zhonghua Jie He He Hu Xi Za Zhi. 1998 Apr;21(4):229-32. Chinese. PubMed PMID: 11326971.

4: Shi Z, Luo W, Xiu Q, Ye Y, Yan Z, Zhu Q. Effects of BRL 55 834 on allergen-induced bronchoconstriction and airway inflammation in sensitized guinea pigs. Chin Med J (Engl). 1999 Nov;112(11):988-91. PubMed PMID: 11721481.

5: Edwards G, Schneider J, Niederste-Hollenberg A, Noack T, Weston AH. Effects of BRL55834 in rat portal vein and bovine trachea: evidence for the induction of a glibenclamide-resistant, ATP-sensitive potassium current. Br J Pharmacol. 1995 Jul;115(6):1027-37. PubMed PMID: 7582499; PubMed Central PMCID: PMC1909032.