K00135

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558243

CAS#: 869650-21-5

Description: K00135 is a potent and selective inhibitor of PIM kinases. K00135 was shown to impair survival and clonogenic growth of a panel of human acute leukemia cells. Exposure to K00135 also significantly suppressed in vitro growth of leukemic blasts from five acute myelogenous leukemia patients but not of normal umbilical cord blood mononuclear cells.


Chemical Structure

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K00135
CAS# 869650-21-5

Theoretical Analysis

MedKoo Cat#: 558243
Name: K00135
CAS#: 869650-21-5
Chemical Formula: C18H18N4O
Exact Mass: 306.1481
Molecular Weight: 306.36
Elemental Analysis: C, 70.57; H, 5.92; N, 18.29; O, 5.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: K00135; K-00135; K 00135;

IUPAC/Chemical Name: 1-[3-[6-[(Cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]phenyl]-ethanone

InChi Key: IVUBNTNWKIPCPS-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H18N4O/c1-12(23)14-3-2-4-15(9-14)16-11-20-18-8-7-17(21-22(16)18)19-10-13-5-6-13/h2-4,7-9,11,13H,5-6,10H2,1H3,(H,19,21)

SMILES Code: CC(C1=CC=CC(C2=CN=C3C=CC(NCC4CC4)=NN32)=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 306.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Darby RA, Unsworth A, Knapp S, Kerr ID, Callaghan R. Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors. Cancer Chemother Pharmacol. 2015 Oct;76(4):853-64. doi: 10.1007/s00280-015-2858-9. Epub 2015 Sep 9. PubMed PMID: 26351135.

2: Yan B, Yau EX, Samanta S, Ong CW, Yong KJ, Ng LK, Bhattacharya B, Lim KH, Soong R, Yeoh KG, Deng N, Tan P, Lam Y, Salto-Tellez M; Singapore Gastric Cancer Consortium. Clinical and therapeutic relevance of PIM1 kinase in gastric cancer. Gastric Cancer. 2012 Apr;15(2):188-97. doi: 10.1007/s10120-011-0097-2. Epub 2011 Oct 13. PubMed PMID: 21993851.

3: Pogacic V, Bullock AN, Fedorov O, Filippakopoulos P, Gasser C, Biondi A, Meyer-Monard S, Knapp S, Schwaller J. Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. Cancer Res. 2007 Jul 15;67(14):6916-24. PubMed PMID: 17638903.

4: Taparowsky EJ, Gerbi SA. Structure of 1.71 lb gm/cm(3) bovine satellite DNA: evolutionary relationship to satellite I. Nucleic Acids Res. 1982 Sep 25;10(18):5503-15. PubMed PMID: 6292843; PubMed Central PMCID: PMC320891.