WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571473
Description: D21-6076 is a β-1,6-Glucan inhibitor. These inhibitors work as antifungal drugs by targeting the fungal cell wall. As glucan is a major component of the cell wall, specifically β-1,6-Glucan, these drugs can help fight fungal infections by degrading glucan or stopping production by inhibiting its synthase. D21-6076 is a pyridobenzimidazole derivative that achieves this function, and is effective against Candida strains (even fluconazole-resistant strains). As an improvement to D75-4590, it is active orally.
MedKoo Cat#: 571473
Chemical Formula: C24H24N6
Exact Mass: 396.2062
Molecular Weight: 396.5
Elemental Analysis: C, 72.70; H, 6.10; N, 21.20
Synonym: D21-6076; D216076; D21 6076
IUPAC/Chemical Name: 6-(3-(dimethylamino)pyrrolidin-1-yl)-8-methyl-7-phenylimidazo[1,2-a:4,5-b']dipyridine-9-carbonitrile
InChi Key: MRZRZGFKBHEXEA-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H24N6/c1-16-19(14-25)23-27-22-20(10-7-12-26-22)30(23)24(21(16)17-8-5-4-6-9-17)29-13-11-18(15-29)28(2)3/h4-10,12,18H,11,13,15H2,1-3H3
SMILES Code: N#CC1=C(C)C(C2=CC=CC=C2)=C(N3CC(N(C)C)CC3)N4C5=CC=CN=C5N=C41
There is increasing morbidity and mortality resulting from invasive fungal infections (IFIs) and antifungal drug resistance. As a result, several drug therapies are addressing the need by discovering and designing new antifungal drug targets and mechanisms, specifically against the most common fungi causing IFIs: Candida, Cryptococcus, and Aspergillus species. Existing drugs (polyenes, azoles, and echinocandins) have limited clinical efficacy, narrow antifungal spectrum, unfavorable pharmacokinetic profiles, significant side effects, drug−drug interactions, and resistance issues.
1: Kitamura A, Higuchi S, Hata M, Kawakami K, Yoshida K, Namba K, Nakajima R. Effect of beta-1,6-glucan inhibitors on the invasion process of Candida albicans: potential mechanism of their in vivo efficacy. Antimicrob Agents Chemother. 2009 Sep;53(9):3963-71. doi: 10.1128/AAC.00435-09. Epub 2009 Jul 13. PubMed PMID: 19596881; PubMed Central PMCID: PMC2737848.
2: Kitamura A, Someya K, Okumura R, Hata M, Takeshita H, Nakajima R. In vitro antifungal activities of D11-2040, a beta-1,6-glucan inhibitor, with or without currently available antifungal drugs. Biol Pharm Bull. 2010;33(2):192-7. PubMed PMID: 20118539.
1: Liu N, Tu J, Dong G, Wang Y, Sheng C. Emerging New Targets for the Treatment of Resistant Fungal Infections. J Med Chem. 2018 Jan 16. doi:
10.1021/acs.jmedchem.7b01413. [Epub ahead of print] PubMed PMID: 29294275.