Dansylamide
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MedKoo CAT#: 555133

CAS#: 1431-39-6

Description: Dansylamide is a reactive fluorescent dye that is used in biochemistry and chemistry to label substances with the fluorescent dansyl group. It is also produced as a side-product in the labelling of amino acids with dansyl chloride.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 225 2 Weeks
50g USD 380 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

Dansylamide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555133
Name: Dansylamide
CAS#: 1431-39-6
Chemical Formula: C12H14N2O2S
Exact Mass: 250.0776
Molecular Weight: 250.316
Elemental Analysis: C, 57.58; H, 5.64; N, 11.19; O, 12.78; S, 12.81


Synonym: Dansylamide

IUPAC/Chemical Name: 5-Dimethylaminonaphthalene-1-sulfonamide

InChi Key: TYNBFJJKZPTRKS-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14N2O2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3,(H2,13,15,16)

SMILES Code: O=S(C1=C2C=CC=C(N(C)C)C2=CC=C1)(N)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Tripathi AK. A Fluorescence Study on Binding Interaction of N-acetylated Dansylamide Conjugates with β-cyclodextrin, Tween-20 and DPPC Lipid Bilayer Membrane. J Fluoresc. 2017 Dec 26. doi: 10.1007/s10895-017-2202-3. [Epub ahead of print] PubMed PMID: 29277860.

2: Yang H, Huang Y, Liu J, Tang P, Sun Q, Xiong X, Tang B, He J, Li H. Binding modes of environmental endocrine disruptors to human serum albumin: insights from STD-NMR, ITC, spectroscopic and molecular docking studies. Sci Rep. 2017 Sep 11;7(1):11126. doi: 10.1038/s41598-017-11604-3. PubMed PMID: 28894220; PubMed Central PMCID: PMC5593971.

3: Devadasan C, Starr B, Doyle KM. Effect of N1-dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the reserpinized mouse model of Parkinson's disease. Neuroreport. 2016 Dec 7;27(17):1243-1247. PubMed PMID: 27653937.

4: Tripathi AK, Mohapatra M, Mishra AK. Fluorescence of N-acylated dansylamide with a long hydrophobic tail: sensitive response to premicellar aggregation of sodium deoxycholate. Phys Chem Chem Phys. 2015 Nov 28;17(44):29985-94. doi: 10.1039/c5cp04263a. Epub 2015 Oct 23. PubMed PMID: 26495442.

5: Szkudlarek A, Maciążek-Jurczyk M, Chudzik M, Równicka-Zubik J, Sułkowska A. Alteration of human serum albumin tertiary structure induced by glycation. Spectroscopic study. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15;153:560-5. doi: 10.1016/j.saa.2015.09.018. Epub 2015 Sep 28. PubMed PMID: 26433342.

6: Ruiz A, Gutiérrez L, Cáceres-Vélez PR, Santos D, Chaves SB, Fascineli ML, Garcia MP, Azevedo RB, Morales MP. Biotransformation of magnetic nanoparticles as a function of coating in a rat model. Nanoscale. 2015 Oct 21;7(39):16321-9. doi: 10.1039/c5nr03780h. PubMed PMID: 26381991.

7: Heinisch T, Pellizzoni M, Dürrenberger M, Tinberg CE, Köhler V, Klehr J, Häussinger D, Baker D, Ward TR. Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design. J Am Chem Soc. 2015 Aug 19;137(32):10414-9. doi: 10.1021/jacs.5b06622. Epub 2015 Aug 7. PubMed PMID: 26226626.

8: Kumar A, Kim HS. N-(3-Imidazolyl)propyl dansylamide as a selective Hg(2+) sensor in aqueous media through electron transfer. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Sep 5;148:250-4. doi: 10.1016/j.saa.2015.03.091. Epub 2015 Mar 28. PubMed PMID: 25897719.

9: Bhoi AK, Das SK, Majhi D, Sahu PK, Nijamudheen A, N A, Rahaman A, Sarkar M. Analyte interactions with a new ditopic dansylamide-nitrobenzoxadiazole dyad: a combined photophysical, NMR, and theoretical (DFT) study. J Phys Chem B. 2014 Aug 21;118(33):9926-37. doi: 10.1021/jp504631n. Epub 2014 Aug 12. PubMed PMID: 25116958.

10: Wagner-Rousset E, Janin-Bussat MC, Colas O, Excoffier M, Ayoub D, Haeuw JF, Rilatt I, Perez M, Corvaïa N, Beck A. Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion. MAbs. 2014 Jan-Feb;6(1):173-84. PubMed PMID: 25006625.

11: Wagner-Rousset E, Janin-Bussat MC, Colas O, Excoffier M, Ayoub D, Haeuw JF, Rilatt I, Perez M, Corvaïa N, Beck A. Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion. MAbs. 2014 Jan-Feb;6(1):273-85. PubMed PMID: 24135617; PubMed Central PMCID: PMC3929440.

12: Er JC, Vendrell M, Tang MK, Zhai D, Chang YT. Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin. ACS Comb Sci. 2013 Sep 9;15(9):452-7. doi: 10.1021/co400060b. Epub 2013 Aug 23. PubMed PMID: 23941241.

13: Xu Y, Liu Q, Li X, Wesdemiotis C, Pang Y. A zwitterionic squaraine dye with a large Stokes shift for in vivo and site-selective protein sensing. Chem Commun (Camb). 2012 Nov 28;48(92):11313-5. doi: 10.1039/c2cc36285f. PubMed PMID: 23079613.

14: zhang Y, Yang X, Liu L, Huang X, Pu J, Long G, Zhang L, Liu D, Xu B, Liao J, Liao F. Comparison of Förster-resonance-energy-transfer acceptors for tryptophan and tyrosine residues in native proteins as donors. J Fluoresc. 2013 Jan;23(1):147-57. doi: 10.1007/s10895-012-1128-z. Epub 2012 Sep 22. Erratum in: J Fluoresc. 2013 Jan;23(1):159. Huang, Zuexia [corrected to Huang, Xuexia]. PubMed PMID: 23001429.

15: Joubert J, van Dyk S, Green IR, Malan SF. Synthesis, evaluation and application of polycyclic fluorescent analogues as N-methyl-D-aspartate receptor and voltage gated calcium channel ligands. Eur J Med Chem. 2011 Oct;46(10):5010-20. doi: 10.1016/j.ejmech.2011.08.008. Epub 2011 Aug 11. PubMed PMID: 21868136.

16: Wu X, Liu J, Wang Q, Xue W, Yao X, Zhang Y, Jin J. Spectroscopic and molecular modeling evidence of clozapine binding to human serum albumin at subdomain IIA. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1202-9. doi: 10.1016/j.saa.2011.04.043. Epub 2011 May 13. PubMed PMID: 21640635.

17: Neff KL, Offord CP, Caride AJ, Strehler EE, Prendergast FG, Bajzer Z. Validation of fractal-like kinetic models by time-resolved binding kinetics of dansylamide and carbonic anhydrase in crowded media. Biophys J. 2011 May 18;100(10):2495-503. doi: 10.1016/j.bpj.2011.04.016. PubMed PMID: 21575584; PubMed Central PMCID: PMC3093561.

18: Cao J, Guo LH, Wan B, Wei Y. In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A. J Environ Sci (China). 2011;23(2):315-21. PubMed PMID: 21517007.

19: Marin M, Lhiaubet-Vallet V, Miranda MA. Site-dependent photo-fries rearrangement within serum albumins. J Phys Chem B. 2011 Mar 31;115(12):2910-5. doi: 10.1021/jp2009463. Epub 2011 Mar 8. PubMed PMID: 21384817.

20: Morcos EF, Kussrow A, Enders C, Bornhop D. Free-solution interaction assay of carbonic anhydrase to its inhibitors using back-scattering interferometry. Electrophoresis. 2010 Nov;31(22):3691-5. doi: 10.1002/elps.201000389. PubMed PMID: 20972990; PubMed Central PMCID: PMC3997304.