Belfosdil

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MedKoo CAT#: 584232

CAS#: 103486-79-9

Description: Belfosdil is an antihypertensive calcium channel blocker.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-08-11. Prices are subject to change without notice.

Belfosdil is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584232
Name: Belfosdil
CAS#: 103486-79-9
Chemical Formula: C27H50O7P2
Exact Mass: 548.3032
Molecular Weight: 548.6375
Elemental Analysis: C, 59.11; H, 9.19; O, 20.41; P, 11.29


Synonym: Belfosdil

IUPAC/Chemical Name: Phosphonic acid, (2-(2-phenoxyethyl)-1,3-propanediyl)bis-, tetrabutyl ester

InChi Key: QTBMDDQRDDABNC-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H50O7P2/c1-5-9-19-31-35(28,32-20-10-6-2)24-26(18-23-30-27-16-14-13-15-17-27)25-36(29,33-21-11-7-3)34-22-12-8-4/h13-17,26H,5-12,18-25H2,1-4H3

SMILES Code: O=P(CC(CCOC1=CC=CC=C1)CP(OCCCC)(OCCCC)=O)(OCCCC)OCCCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Bosco D, Gonelle-Gispert C, Wollheim CB, Halban PA, Rouiller DG. Increased intracellular calcium is required for spreading of rat islet beta-cells on extracellular matrix. Diabetes. 2001 May;50(5):1039-46. PubMed PMID: 11334406.

2: Rutter GA, Theler JM, Murgia M, Wollheim CB, Pozzan T, Rizzuto R. Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion. J Biol Chem. 1993 Oct 25;268(30):22385-90. PubMed PMID: 8226749.

3: Mulvana DE, Kaul S, Dandekar KA, Pittman KA. Determination of belfosdil, a new calcium channel blocker, in human plasma by capillary gas chromatography with nitrogen-phosphorus detection. J Chromatogr. 1990 May 18;527(2):343-50. PubMed PMID: 2387881.

4: Kennedy ED, Rizzuto R, Theler JM, Pralong WF, Bastianutto C, Pozzan T, Wollheim CB. Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells. J Clin Invest. 1996 Dec 1;98(11):2524-38. PubMed PMID: 8958215; PubMed Central PMCID: PMC507710.

5: Li G, Hidaka H, Wollheim CB. Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels. Mol Pharmacol. 1992 Sep;42(3):489-8. PubMed PMID: 1328847.

6: Rossier JR, Cox JA, Niesor EJ, Bentzen CL. A new class of calcium entry blockers defined by 1,3-diphosphonates. Interactions of SR-7037 (belfosdil) with receptors for calcium channel ligands. J Biol Chem. 1989 Oct 5;264(28):16598-607. PubMed PMID: 2550449.