AKP-11
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555131

CAS#: 1220973-37-4

Description: AKP-11 is A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis. AKP-11 is the next generation of S1P1 agonist with immunomodulatory activities in cell culture model and for therapeutic efficacy against an animal model of MS, i.e. experimental autoimmune encephalomyelitis (EAE) but without the adverse effects observed with FTY720.


Price and Availability

Size
Price

500mg
USD 2750
5g
USD 11950
Size
Price

1g
USD 3650
10g
USD 21950
Size
Price

2g
USD 5850

AKP-11, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555131
Name: AKP-11
CAS#: 1220973-37-4
Chemical Formula: C22H22ClN3O5
Exact Mass: 443.1248
Molecular Weight: 443.884
Elemental Analysis: C, 59.53; H, 5.00; Cl, 7.99; N, 9.47; O, 18.02


Synonym: AKP-11; AKP 11; AKP11.

IUPAC/Chemical Name: 2-Amino-2-[5-[5-(3-chloro-4-propoxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl]propane-1,3-diol

InChi Key: YHNUTRJSCOJJKX-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H22ClN3O5/c1-2-7-29-18-6-4-14(9-16(18)23)21-25-20(26-31-21)13-3-5-17-15(8-13)10-19(30-17)22(24,11-27)12-28/h3-6,8-10,27-28H,2,7,11-12,24H2,1H3

SMILES Code: OCC(C(O1)=CC2=C1C=CC(C3=NOC(C4=CC=C(OCCC)C(Cl)=C4)=N3)=C2)(N)CO


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Sphingosine-1-phosphate receptor 1 (S1P1) mediated regulation of lymphocyte egress from lymphoid organs is recognized as the mechanism of FTY720 (Fingolimod, Gilenya) efficacy in relapsing-remitting forms of multiple sclerosis (RRMS).


References

1: Samuvel DJ, Saxena N, Dhindsa JS, Singh AK, Gill GS, Grobelny DW, Singh I.
AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates
Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis.
PLoS One. 2015 Oct 29;10(10):e0141781. doi: 10.1371/journal.pone.0141781.
eCollection 2015. PubMed PMID: 26513477; PubMed Central PMCID: PMC4626178.