Azintamide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584221

CAS#: 1830-32-6

Description: Azintamide is a choleretic that has shown effective and safe for dyspepsia symptoms when Domperidone therapy is not satisfactory.


Chemical Structure

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Azintamide
CAS# 1830-32-6

Theoretical Analysis

MedKoo Cat#: 584221
Name: Azintamide
CAS#: 1830-32-6
Chemical Formula: C10H14ClN3OS
Exact Mass: 259.05
Molecular Weight: 259.752
Elemental Analysis: C, 46.24; H, 5.43; Cl, 13.65; N, 16.18; O, 6.16; S, 12.34

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Azintamide; Azinthiamide; Bilipurum; BRN 0885011; Colerin; Oragalin

IUPAC/Chemical Name: (6-Chlorpyridazin-3-ylthio)diethylacetamide

InChi Key: SSLKKMZJCJBOML-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H14ClN3OS/c1-3-14(4-2)10(15)7-16-9-6-5-8(11)12-13-9/h5-6H,3-4,7H2,1-2H3

SMILES Code: O=C(N(CC)CC)CSC1=NN=C(Cl)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 259.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: NEUGEBAUER W. [ORAGALLIN--A NEW CHOLERETIC]. Hippokrates. 1965 Jan 15;36:25-8. German. PubMed PMID: 14299536.

2: Abdel-Moety EM. Gas-liquid chromatographic determination of azintamide (Ora-gallin) in pharmaceutical formulations. J Chromatogr. 1985 May 24;324(2):475-9. PubMed PMID: 4008559.

3: Mestrovic N. [On the choleretic activity of Azintamid after cholecystectomy]. Med Welt. 1968 Apr 27;17:1155-8. German. PubMed PMID: 5727882.

4: Diezel W, Brenke A, Sönnichsen N. [Azintamid as a therapeutic agent in psoriasis vulgaris - a therapeutic study]. Dermatol Monatsschr. 1983;169(8):521-4. German. PubMed PMID: 6628788.

5: Zhao L, Xu L, Li Q, Wang XD, Wang DM, Wang ZG. [Combination therapy of azintamid and domperidone in functional dyspepsia: a randomised, double-blind, placebo-controlled trial]. Zhonghua Nei Ke Za Zhi. 2011 Mar;50(3):212-5. Chinese. PubMed PMID: 21600084.

6: Zhu LM, Qian JM, Xu L, Zhao HC, Yang YS, Zhang M, Liu YL, Xie PY, Hao JY, Han SM. [Efficacy and safety of compound azintamide on dyspepsia symptoms in a multicentre self-controlled trial]. Zhonghua Nei Ke Za Zhi. 2008 Nov;47(11):910-3. Chinese. PubMed PMID: 19080231.

7: Hegazy MA, Hassanain WA, Abdel Fattah LE, El-Fatatry HM. Chromatographic Study of Azintamide in Bulk Powder and in Pharmaceutical Formulation in the Presence of Its Degradation Form. J AOAC Int. 2017 Mar 1;100(2):422-428. doi: 10.5740/jaoacint.16-0049. Epub 2016 Nov 15. PubMed PMID: 28118567.