AC1903
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561805

CAS#: 831234-13-0

Description: AC1903 is a specific blocker of TRPC5 channel activity. It has been shown to suppress severe proteinuria and prevent podocyte loss.


Chemical Structure

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AC1903
CAS# 831234-13-0

Theoretical Analysis

MedKoo Cat#: 561805
Name: AC1903
CAS#: 831234-13-0
Chemical Formula: C19H17N3O
Exact Mass: 303.1372
Molecular Weight: 303.36
Elemental Analysis: C, 75.23; H, 5.65; N, 13.85; O, 5.27

Price and Availability

Size Price Availability Quantity
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 2650.0 2 Weeks
1.0g USD 3850.0 2 Weeks
2.0g USD 6450.0 2 Weeks
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Synonym: AC1903; AC-1903; AC 1903;

IUPAC/Chemical Name: 1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine

InChi Key: OECUWHDVQIITIS-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17N3O/c1-2-7-15(8-3-1)14-22-18-11-5-4-10-17(18)21-19(22)20-13-16-9-6-12-23-16/h1-12H,13-14H2,(H,20,21)

SMILES Code: C1(NCC2=CC=CO2)=NC3=CC=CC=C3N1CC4=CC=CC=C4

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Biological target: AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties.
In vitro activity: TBD
In vivo activity: Twice-daily intraperitoneal injections of AC1903 (50 mg/kg) for 7 days suppressed severe proteinuria in AT1R Tg rats (Advanced) (Fig. 3A), without evidence of toxicity (fig. S7, A to C). Inside-out electrophysiology measurements in isolated glomeruli from AT1R Tg rats confirmed that AC1903 blocks TRPC5 channel activity during proteinuric disease progression (Fig. 3, B and C). Morphometric analysis demonstrated that treatment with AC1903 led to a significant reduction in pseudocyst formation and in podocyte loss in AT1R Tg rats with advanced disease (Fig. 3, D to F). Thus, AC1903 inhibits the progression of proteinuric kidney disease by preserving podocytes. Reference: Science. 2017 Dec 8; 358(6368): 1332–1336. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014699/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.29 169.07
DMSO:PBS (pH 7.2) (1:4) 0.2 0.66
DMF 30.0 98.89
Ethanol 30.5 100.54

Preparing Stock Solutions

The following data is based on the product molecular weight 303.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Sharma SH, Pablo JL, Montesinos MS, Greka A, Hopkins CR. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg Med Chem Lett. 2019 Jan 15;29(2):155-159. doi: 10.1016/j.bmcl.2018.12.007. Epub 2018 Dec 4. PMID: 30538066; PMCID: PMC6349029. 2. Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017 Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178. PMID: 29217578; PMCID: PMC6014699.
In vitro protocol: TBD
In vivo protocol: 1. Sharma SH, Pablo JL, Montesinos MS, Greka A, Hopkins CR. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg Med Chem Lett. 2019 Jan 15;29(2):155-159. doi: 10.1016/j.bmcl.2018.12.007. Epub 2018 Dec 4. PMID: 30538066; PMCID: PMC6349029. 2. Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017 Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178. PMID: 29217578; PMCID: PMC6014699.

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1: Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017 Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178. PubMed PMID: 29217578.

AC1903

50.0mg / USD 450.0