WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561804
CAS#: 1202388-64-4
Description: IAXO-101 interferes with human, rat and mouse TLR4/CD14 signaling.
MedKoo Cat#: 561804
Name: IAXO-101
CAS#: 1202388-64-4
Chemical Formula: C42H84INO5
Exact Mass:
Molecular Weight: 810.04
Elemental Analysis: C, 62.28; H, 10.45; I, 15.67; N, 1.73; O, 9.88
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: IAXO-101; IAXO 101; IAXO101;
IUPAC/Chemical Name: N-(((2R,3R,4S,5R,6S)-3-hydroxy-6-methoxy-4,5-bis(tetradecyloxy)tetrahydro-2H-pyran-2-yl)methyl)-N,N-dimethylcyclopentanaminium iodide
InChi Key: BEFLBKFGGQBVHS-MDMJKWFXSA-M
InChi Code: InChI=1S/C42H84NO5.HI/c1-6-8-10-12-14-16-18-20-22-24-26-30-34-46-40-39(44)38(36-43(3,4)37-32-28-29-33-37)48-42(45-5)41(40)47-35-31-27-25-23-21-19-17-15-13-11-9-7-2;/h37-42,44H,6-36H2,1-5H3;1H/q+1;/p-1/t38-,39-,40+,41-,42+;/m1./s1
SMILES Code: C[N+](C)(C[C@@H]1[C@@H](O)[C@H](OCCCCCCCCCCCCCC)[C@@H](OCCCCCCCCCCCCCC)[C@@H](OC)O1)C2CCCC2.[I-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 810.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hermann JK, Ravikumar M, Shoffstall A, Ereifej ES, Kovach K, Chang J, Soffer A, Wong CT, Srivastava V, Smith P, Protasiewicz G, Jiang J, Selkirk S, Miller RH, Sidik S, Ziats NP, Taylor D, Capadona JR. Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance. J Neural Eng. 2017 Dec 8. doi: 10.1088/1741-2552/aaa03e. [Epub ahead of print] PubMed PMID: 29219114.
2: Barboza R, Lima FA, Reis AS, Murillo OJ, Peixoto EPM, Bandeira CL, Fotoran WL, Sardinha LR, Wunderlich G, Bevilacqua E, Lima MRD, Alvarez JM, Costa FTM, Gonçalves LA, Epiphanio S, Marinho CRF. TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria. Sci Rep. 2017 Aug 17;7(1):8623. doi: 10.1038/s41598-017-08299-x. PubMed PMID: 28819109; PubMed Central PMCID: PMC5561130.
