J-104129 fumarate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561799

CAS#: 257603-40-0

Description: J-104129 fumarate is a potent M3 muscarinic receptor antagonist.


Chemical Structure

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J-104129 fumarate
CAS# 257603-40-0

Theoretical Analysis

MedKoo Cat#: 561799
Name: J-104129 fumarate
CAS#: 257603-40-0
Chemical Formula: C28H40N2O6
Exact Mass:
Molecular Weight: 500.63
Elemental Analysis: C, 67.18; H, 8.05; N, 5.60; O, 19.17

Size Price Shipping out time Quantity
5mg USD 250 2 Weeks
25mg USD 650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-05. Prices are subject to change without notice.

J-104129 fumarate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: J-104129 fumarate; J 104129 fumarate; J104129 fumarate;

IUPAC/Chemical Name: (R)-2-Cyclopentyl-2-hydroxy-N-[1-(4-methyl-pent-3-enyl)-piperidin-4-yl]-2-phenyl-acetamide fumarate

InChi Key: HUCQUCITPHOUAC-DSSYAJFBSA-N

InChi Code: InChI=1S/C24H36N2O2.C4H4O4/c1-19(2)9-8-16-26-17-14-22(15-18-26)25-23(27)24(28,21-12-6-7-13-21)20-10-4-3-5-11-20;5-3(6)1-2-4(7)8/h3-5,9-11,21-22,28H,6-8,12-18H2,1-2H3,(H,25,27);1-2H,(H,5,6)(H,7,8)/b;2-1+/t24-;/m0./s1

SMILES Code: O=C(NC1CCN(CC/C=C(C)/C)CC1)[C@@](O)(C2CCCC2)C3=CC=CC=C3.O=C(O)/C=C/C(O)=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 500.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Tsentsevitsky AN, Kovyazina IV, Nurullin LF, Nikolsky EE. Muscarinic cholinoreceptors (M1-, M2-, M3- and M4-type) modulate the acetylcholine secretion in the frog neuromuscular junction. Neurosci Lett. 2017 May 10;649:62-69. doi: 10.1016/j.neulet.2017.04.015. Epub 2017 Apr 10. PubMed PMID: 28408330.

2: Odagaki Y, Kinoshita M, Toyoshima R. Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes. J Pharmacol Sci. 2014;125(2):157-68. Epub 2014 May 20. PubMed PMID: 24849282.

3: Sterin-Borda L, Orman B, De Couto Pita A, Borda E. Inflammation triggers constitutive activity and agonist-induced negative responses at M(3) muscarinic receptor in dental pulp. J Endod. 2011 Feb;37(2):185-90. doi: 10.1016/j.joen.2010.11.021. PubMed PMID: 21238800.