WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561799
CAS#: 257603-40-0
Description: J-104129 fumarate is a potent M3 muscarinic receptor antagonist.
MedKoo Cat#: 561799
Name: J-104129 fumarate
CAS#: 257603-40-0
Chemical Formula: C28H40N2O6
Exact Mass:
Molecular Weight: 500.63
Elemental Analysis: C, 67.18; H, 8.05; N, 5.60; O, 19.17
Synonym: J-104129 fumarate; J 104129 fumarate; J104129 fumarate;
IUPAC/Chemical Name: (R)-2-Cyclopentyl-2-hydroxy-N-[1-(4-methyl-pent-3-enyl)-piperidin-4-yl]-2-phenyl-acetamide fumarate
InChi Key: HUCQUCITPHOUAC-DSSYAJFBSA-N
InChi Code: InChI=1S/C24H36N2O2.C4H4O4/c1-19(2)9-8-16-26-17-14-22(15-18-26)25-23(27)24(28,21-12-6-7-13-21)20-10-4-3-5-11-20;5-3(6)1-2-4(7)8/h3-5,9-11,21-22,28H,6-8,12-18H2,1-2H3,(H,25,27);1-2H,(H,5,6)(H,7,8)/b;2-1+/t24-;/m0./s1
SMILES Code: O=C(NC1CCN(CC/C=C(C)/C)CC1)[C@@](O)(C2CCCC2)C3=CC=CC=C3.O=C(O)/C=C/C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 500.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Tsentsevitsky AN, Kovyazina IV, Nurullin LF, Nikolsky EE. Muscarinic cholinoreceptors (M1-, M2-, M3- and M4-type) modulate the acetylcholine secretion in the frog neuromuscular junction. Neurosci Lett. 2017 May 10;649:62-69. doi: 10.1016/j.neulet.2017.04.015. Epub 2017 Apr 10. PubMed PMID: 28408330.
2: Odagaki Y, Kinoshita M, Toyoshima R. Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes. J Pharmacol Sci. 2014;125(2):157-68. Epub 2014 May 20. PubMed PMID: 24849282.
3: Sterin-Borda L, Orman B, De Couto Pita A, Borda E. Inflammation triggers constitutive activity and agonist-induced negative responses at M(3) muscarinic receptor in dental pulp. J Endod. 2011 Feb;37(2):185-90. doi: 10.1016/j.joen.2010.11.021. PubMed PMID: 21238800.
