JNJ303
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561798

CAS#: 878489-28-2

Description: JNJ303 is a specific inhibitor of heteromeric Kv7.1/KCNE1 channel complexes in a concentration- and time-dependent manner.


Chemical Structure

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JNJ303
CAS# 878489-28-2

Theoretical Analysis

MedKoo Cat#: 561798
Name: JNJ303
CAS#: 878489-28-2
Chemical Formula: C21H29ClN2O4S
Exact Mass: 440.1537
Molecular Weight: 440.98
Elemental Analysis: C, 57.20; H, 6.63; Cl, 8.04; N, 6.35; O, 14.51; S, 7.27

Price and Availability

Size Price Availability Quantity
10.0mg USD 320.0 2 Weeks
50.0mg USD 950.0 2 Weeks
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Synonym: JNJ303; JNJ-303; JNJ 303; AC-1; AC 1; AC1;

IUPAC/Chemical Name: 2-(4-Chloro-phenoxy)-N-(5-methanesulfonylamino-adamantan-2-yl)-2-methyl-propionamide

InChi Key: OSGIRCJRKSAODN-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H29ClN2O4S/c1-20(2,28-17-6-4-16(22)5-7-17)19(25)23-18-14-8-13-9-15(18)12-21(10-13,11-14)24-29(3,26)27/h4-7,13-15,18,24H,8-12H2,1-3H3,(H,23,25)

SMILES Code: CC(C)(OC1=CC=C(Cl)C=C1)C(NC2C3CC4CC(C3)(NS(=O)(C)=O)CC2C4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 440.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Altomare C, Pianezzi E, Cervio E, Bolis S, Biemmi V, Benzoni P, Camici GG, Moccetti T, Barile L, Vassalli G. Human-induced pluripotent stem cell-derived cardiomyocytes from cardiac progenitor cells: effects of selective ion channel blockade. Europace. 2016 Dec;18(suppl 4):iv67-iv76. doi: 10.1093/europace/euw352. PubMed PMID: 28011833.

2: Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G. KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting. Nat Commun. 2016 Oct 12;7:12795. doi: 10.1038/ncomms12795. PubMed PMID: 27731317; PubMed Central PMCID: PMC5064022.

3: Kuusela J, Kim J, Räsänen E, Aalto-Setälä K. The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes. Stem Cell Rev. 2016 Dec;12(6):698-707. PubMed PMID: 27646833; PubMed Central PMCID: PMC5106508.

4: Zhang X, Guo L, Zeng H, White SL, Furniss M, Balasubramanian B, Lis E, Lagrutta A, Sannajust F, Zhao LL, Xi B, Wang X, Davis M, Abassi YA. Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:201-16. doi: 10.1016/j.vascn.2016.06.004. Epub 2016 Jun 7. PubMed PMID: 27282640.

5: Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL. Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Res. 2013 Jan;10(1):48-56. doi: 10.1016/j.scr.2012.08.007. Epub 2012 Sep 7. PubMed PMID: 23089628.

6: Guns PJ, Johnson DM, Weltens E, Lissens J. Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pig. J Pharmacol Toxicol Methods. 2012 Sep;66(2):125-34. doi: 10.1016/j.vascn.2012.03.007. Epub 2012 Apr 9. PubMed PMID: 22516473.

JNJ303

10.0mg / USD 320.0