BRD6989
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407868

CAS#: 642008-81-9

Description: BRD6989 is a selective CDK8 inhibitor. The ability of BRD6989 to upregulate IL-10 is recapitulated by multiple, structurally differentiated CDK8 and CDK19 inhibitors and requires an intact cyclin C-CDK8 complex. BRD6989 demonstrated a high selectivity for CDK8 over CDK19. In bone-marrow-derived dendritic cells, BRD6989 suppressed the phosphorylation of STAT1 at S727 and enhanced the production of IL-10, suggesting CDK8 as a negative regulator of IL-10 production during innate immune activation. BRD6989 may be useful for inflammatory disorders.

Chemical Structure

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BRD6989
CAS# 642008-81-9
Instruction

Theoretical Analysis

MedKoo Cat#: 407868
Name: BRD6989
CAS#: 642008-81-9
Chemical Formula: C16H16N4
Exact Mass: 264.14
Molecular Weight: 264.332
Elemental Analysis: C, 72.70; H, 6.10; N, 21.20

Price and Availability

Size Price Availability Quantity
10mg USD 310 2 Weeks
50mg USD 995 2 Weeks
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Synonym: BRD6989; BRD-6989; BRD 6989.

IUPAC/Chemical Name: 2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

InChi Key: QSYBDNXNOJIKML-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H16N4/c1-10-4-5-14-12(7-10)15(11-3-2-6-19-9-11)13(8-17)16(18)20-14/h2-3,6,9-10H,4-5,7H2,1H3,(H2,18,20)

SMILES Code: NC1=C(C#N)C(C2=CN=CC=C2)=C3C(CCC(C)C3)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Enhancing production of the anti-inflammatory cytokine interleukin-10 (IL-10) is a promising strategy to suppress pathogenic inflammation

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 264.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017 Oct;13(10):1102-1108. doi: 10.1038/nchembio.2458. Epub 2017 Aug 14. PubMed PMID: 28805801; PubMed Central PMCID: PMC5693369.