Butafenacil

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527480

CAS#: 134605-64-4

Description: Butafenacil is a potent inducer of anemia.

Chemical Structure

img
Butafenacil
CAS# 134605-64-4
Instruction

Theoretical Analysis

MedKoo Cat#: 527480
Name: Butafenacil
CAS#: 134605-64-4
Chemical Formula: C20H18ClF3N2O6
Exact Mass: 474.08
Molecular Weight: 474.817
Elemental Analysis: C, 50.59; H, 3.82; Cl, 7.47; F, 12.00; N, 5.90; O, 20.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Butafenacil

IUPAC/Chemical Name: (2-Methyl-1-oxo-1-prop-2-enoxypropan-2-yl) 2-chloro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)pyrimidin-1-yl]benzoate

InChi Key: JEDYYFXHPAIBGR-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H18ClF3N2O6/c1-5-8-31-17(29)19(2,3)32-16(28)12-9-11(6-7-13(12)21)26-15(27)10-14(20(22,23)24)25(4)18(26)30/h5-7,9-10H,1,8H2,2-4H3

SMILES Code: O=C(OC(C)(C)C(OCC=C)=O)C1=CC(N(C(N(C)C(C(F)(F)F)=C2)=O)C2=O)=CC=C1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 474.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Leet JK, Hipszer RA, Volz DC. Butafenacil: A positive control for identifying anemia- and variegate porphyria-inducing chemicals. Toxicol Rep. 2015 Jul 13;2:976-983. doi: 10.1016/j.toxrep.2015.07.006. eCollection 2015. PubMed PMID: 28962437; PubMed Central PMCID: PMC5598413.

2: Byeon Y, Lee HY, Back K. Chloroplastic and cytoplasmic overexpression of sheep serotonin N-acetyltransferase in transgenic rice plants is associated with low melatonin production despite high enzyme activity. J Pineal Res. 2015 May;58(4):461-9. doi: 10.1111/jpi.12231. Epub 2015 Apr 2. PubMed PMID: 25782973.

3: Leet JK, Lindberg CD, Bassett LA, Isales GM, Yozzo KL, Raftery TD, Volz DC. High-content screening in zebrafish embryos identifies butafenacil as a potent inducer of anemia. PLoS One. 2014 Aug 4;9(8):e104190. doi: 10.1371/journal.pone.0104190. eCollection 2014. PubMed PMID: 25090246; PubMed Central PMCID: PMC4121296.

4: Byeon Y, Lee HY, Lee K, Back K. A rice chloroplast transit peptide sequence does not alter the cytoplasmic localization of sheep serotonin N-acetyltransferase expressed in transgenic rice plants. J Pineal Res. 2014 Sep;57(2):147-54. doi: 10.1111/jpi.12151. Epub 2014 Jun 28. PubMed PMID: 24920304.

5: Ivanova B, Spiteller M. UV-MALDI mass spectrometric quantitation of uracil based pesticides in fruit soft drinks along with matrix effects evaluation. Ecotoxicol Environ Saf. 2014 Feb;100:233-41. doi: 10.1016/j.ecoenv.2013.08.005. Epub 2013 Sep 6. PubMed PMID: 24018142.

6: de Pater S, Pinas JE, Hooykaas PJ, van der Zaal BJ. ZFN-mediated gene targeting of the Arabidopsis protoporphyrinogen oxidase gene through Agrobacterium-mediated floral dip transformation. Plant Biotechnol J. 2013 May;11(4):510-5. doi: 10.1111/pbi.12040. Epub 2012 Dec 28. PubMed PMID: 23279135; PubMed Central PMCID: PMC3719044.

7: Park S, Lee DE, Jang H, Byeon Y, Kim YS, Back K. Melatonin-rich transgenic rice plants exhibit resistance to herbicide-induced oxidative stress. J Pineal Res. 2013 Apr;54(3):258-63. doi: 10.1111/j.1600-079X.2012.01029.x. Epub 2012 Aug 1. PubMed PMID: 22856683.

8: Ishiguro M, Mikasa S, Otani M. [A case of acute poisoning caused by the inhalation of a nonselective herbicide REBIN GT SC (butafenacil and glyphosate isopropylamine)]. Chudoku Kenkyu. 2004 Jan;17(1):51-4. Japanese. PubMed PMID: 15079922.

9: Li X, Volrath SL, Nicholl DB, Chilcott CE, Johnson MA, Ward ER, Law MD. Development of protoporphyrinogen oxidase as an efficient selection marker for Agrobacterium tumefaciens-mediated transformation of maize. Plant Physiol. 2003 Oct;133(2):736-47. Epub 2003 Sep 11. PubMed PMID: 12972658; PubMed Central PMCID: PMC219048.

10: Hanin M, Volrath S, Bogucki A, Briker M, Ward E, Paszkowski J. Gene targeting in Arabidopsis. Plant J. 2001 Dec;28(6):671-7. PubMed PMID: 11851913.