MS21570
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561754

CAS#: 65373-29-7

Description: MS21570 is a GPR171 antagonist that reduces anxiety-like behavior and fear conditioning in mice.

Chemical Structure

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MS21570
CAS# 65373-29-7
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 561754
Name: MS21570
CAS#: 65373-29-7
Chemical Formula: C10H11N3S2
Exact Mass: 237.04
Molecular Weight: 237.339
Elemental Analysis: C, 50.61; H, 4.67; N, 17.71; S, 27.02

Price and Availability

Size Price Availability Quantity
10mg USD 250 2 Weeks
50mg USD 470 2 Weeks
100mg USD 730 2 Weeks
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Synonym: MS21570; MS-21570; MS 21570;

IUPAC/Chemical Name: 5-(benzylthio)-N-methyl-1,3,4-thiadiazol-2-amine

InChi Key: KFLNRVSOQJTXDG-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H11N3S2/c1-11-9-12-13-10(15-9)14-7-8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,11,12)

SMILES Code: CNC(S1)=NN=C1SCC2=CC=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: MS21570 is a selective GPR171 antagonist, with an IC50 of 220 nM.
In vitro activity: Displacement binding assays show that MS0021570_1 dose dependently and completely displaced radiolabeled BigLEN binding to hypothalamic membranes albeit with a lower affinity (~31-fold) compared to BigLEN (Figure 1c); MS0015917 only partially (~37%) displaced radiolabeled BigLEN binding (Figure 1c). Reference: Reference: Neuropsychopharmacology. 2017 Dec;42(13):2527-2536. https://pubmed.ncbi.nlm.nih.gov/28425495/
In vivo activity: The role of GPR171 in anxiety-like behavior or fear conditioning was evaluated following systemic or intra-BLA administration of MS0021570_1, as well as following lentiviral-mediated knockdown of GPR171 in the BLA. This study finds that systemic administration of MS0021570_1 attenuates anxiety-like behavior in mice while intra-BLA administration or knockdown of GPR171 in the BLA reduces anxiety-like behavior and fear conditioning. Reference: Neuropsychopharmacology. 2017 Dec;42(13):2527-2536. https://pubmed.ncbi.nlm.nih.gov/28425495/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 74.4 313.33
Ethanol 23.7 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 237.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: Bobeck EN, Gomes I, Pena D, Cummings KA, Clem RL, Mezei M, Devi LA. The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning. Neuropsychopharmacology. 2017 Dec;42(13):2527-2536. doi: 10.1038/npp.2017.79. Epub 2017 Apr 20. PMID: 28425495; PMCID: PMC5686498.
In vitro protocol: Bobeck EN, Gomes I, Pena D, Cummings KA, Clem RL, Mezei M, Devi LA. The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning. Neuropsychopharmacology. 2017 Dec;42(13):2527-2536. doi: 10.1038/npp.2017.79. Epub 2017 Apr 20. PMID: 28425495; PMCID: PMC5686498.
In vivo protocol: Bobeck EN, Gomes I, Pena D, Cummings KA, Clem RL, Mezei M, Devi LA. The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning. Neuropsychopharmacology. 2017 Dec;42(13):2527-2536. doi: 10.1038/npp.2017.79. Epub 2017 Apr 20. PMID: 28425495; PMCID: PMC5686498.

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