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MedKoo CAT#: 555118

CAS#: 1810051-96-7 (free acid)

Description: LYS228, also known as Ancremonam, is a potent antibiotics with Activity against Carbapenem-Resistant Enterobacteriaceae (MIC90 = 2 uM/mL). LYS228 is potent in the presence of all classes of beta-lactamases and shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae (CRE).

Price and Availability

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Pricing updated 2020-10-26. Prices are subject to change without notice.

LYS228 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555118
Name: LYS228
CAS#: 1810051-96-7 (free acid)
Chemical Formula: C16H18N6O10S2
Exact Mass: 518.0526
Molecular Weight: 518.472
Elemental Analysis: C, 37.07; H, 3.50; N, 16.21; O, 30.86; S, 12.37

Related CAS #: 2091840-41-2 (sodium)   1810051-96-7 (free acid)   2091840-42-3 (X hydrate)   2091840-43-4 (trihydrate)    

Synonym: LYS228; LYS-228; LYS 228; Ancremonam

IUPAC/Chemical Name: 1-((((Z)-1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3-yl)amino)ethylidene)amino)oxy)cyclopropane-1-carboxylic acid


InChi Code: InChI=1S/C16H18N6O10S2/c17-14-18-7(6-33-14)9(20-32-16(1-2-16)13(25)26)11(23)19-10-8(5-21-3-4-31-15(21)27)22(12(10)24)34(28,29)30/h6,8,10H,1-5H2,(H2,17,18)(H,19,23)(H,25,26)(H,28,29,30)/b20-9-/t8-,10+/m1/s1

SMILES Code: O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N\OC3(CC3)C(O)=O)=O)[C@@H](CN4CCOC4=O)N1S(=O)(O)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Metallo--lactamases (MBLs), such as New Delhi metallo--lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of -lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clinical utility against MBL-expressing strains because they are impacted by serine -lactamases (SBLs), which are often co-expressed in clinical isolates.


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