WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561733

CAS#: 1155877-97-6

Description: D159687 is a selective negative allosteric modulator (NAM) of PDE4D.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2021-01-28. Prices are subject to change without notice.

D159687 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 561733
Name: D159687
CAS#: 1155877-97-6
Chemical Formula: C21H19ClN2O2
Exact Mass: 366.1135
Molecular Weight: 366.84
Elemental Analysis: C, 68.76; H, 5.22; Cl, 9.66; N, 7.64; O, 8.72

Synonym: D159687; D-159687; D 159687;

IUPAC/Chemical Name: [4-[[3-(3-Chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea


InChi Code: InChI=1S/C21H19ClN2O2/c1-26-20-10-7-15(12-19(20)16-3-2-4-17(22)13-16)11-14-5-8-18(9-6-14)24-21(23)25/h2-10,12-13H,11H2,1H3,(H3,23,24,25)

SMILES Code: O=C(N)NC1=CC=C(CC2=CC=C(OC)C(C3=CC=CC(Cl)=C3)=C2)C=C1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Titus DJ, Wilson NM, Alcazar O, Calixte DA, Dalton Dietrich W, Gurney ME, Atkins CM. A Negative Allosteric Modulator of PDE4D Enhances Learning after Traumatic Brain Injury. Neurobiol Learn Mem. 2017 Dec 30. pii: S1074-7427(17)30216-2. doi: 10.1016/j.nlm.2017.12.008. [Epub ahead of print] PubMed PMID: 29294383.

2: Zhang C, Xu Y, Zhang HT, Gurney ME, O'Donnell JM. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115. doi: 10.1038/srep40115. PubMed PMID: 28054669; PubMed Central PMCID: PMC5215650.

3: Sutcliffe JS, Beaumont V, Watson JM, Chew CS, Beconi M, Hutcheson DM, Dominguez C, Munoz-Sanjuan I. Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis). PLoS One. 2014 Jul 22;9(7):e102449. doi: 10.1371/journal.pone.0102449. eCollection 2014. PubMed PMID: 25050979; PubMed Central PMCID: PMC4106781.

4: Burgin AB, Magnusson OT, Singh J, Witte P, Staker BL, Bjornsson JM, Thorsteinsdottir M, Hrafnsdottir S, Hagen T, Kiselyov AS, Stewart LJ, Gurney ME. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat Biotechnol. 2010 Jan;28(1):63-70. doi: 10.1038/nbt.1598. Epub 2009 Dec 27. PubMed PMID: 20037581.