Ganoderenic Acid D

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561726

CAS#: 100665-43-8

Description: Ganoderenic Acid D is the major active component of Ganoderma lucidum, and acts by inhibiting the growth of numerous cancer cell lines.


Chemical Structure

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Ganoderenic Acid D
CAS# 100665-43-8

Theoretical Analysis

MedKoo Cat#: 561726
Name: Ganoderenic Acid D
CAS#: 100665-43-8
Chemical Formula: C30H40O7
Exact Mass: 512.2774
Molecular Weight: 512.643
Elemental Analysis: C, 70.29; H, 7.87; O, 21.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ganoderenic Acid D;

IUPAC/Chemical Name: (Z)-6-[(5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-1,2,5,6,7,12,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxohept-5-enoic acid

InChi Key: JGWQYLZHPPFHEH-HNXDABDESA-N

InChi Code: InChI=1S/C30H40O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h10,16,18-19,21,32H,8-9,11-14H2,1-7H3,(H,36,37)/b15-10-/t16?,18-,19+,21+,28+,29-,30+/m1/s1

SMILES Code: C/C([C@H]([C@@]1(C)C2)CC([C@@]1(C)C([C@@H](O)C[C@@]3([H])C(C)(C)C(CC[C@]43C)=O)=C4C2=O)=O)=C/C(CC(C)C(O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 512.643 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Che XQ, Li SP, Zhao J. [Ganoderma triterpenoids from aqueous extract of Ganoderma lucidum]. Zhongguo Zhong Yao Za Zhi. 2017 May;42(10):1908-1915. doi: 10.19540/j.cnki.cjcmm.20170412.001. Chinese. PubMed PMID: 29090550.

2: Zhao RL, He YM. Network pharmacology analysis of the anti-cancer pharmacological mechanisms of Ganoderma lucidum extract with experimental support using Hepa1-6-bearing C57 BL/6 mice. J Ethnopharmacol. 2018 Jan 10;210:287-295. doi: 10.1016/j.jep.2017.08.041. Epub 2017 Sep 4. PubMed PMID: 28882624.

3: Liu LY, Kang J, Wu CH, Li Y, Chen RY. [Triterpenoids from Ganoderma theaecolum]. Zhongguo Zhong Yao Za Zhi. 2016 Mar;41(6):1075-1080. doi: 10.4268/cjcmm20160617. Chinese. PubMed PMID: 28875673.

4: Ruan W, Lim AH, Huang LG, Popovich DG. Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. Nat Prod Res. 2014;28(24):2264-72. doi: 10.1080/14786419.2014.938337. Epub 2014 Jul 17. PubMed PMID: 25032738.

5: Li BM, Gu HF, Li Y, Liu C, Wang HQ, Kang J, Wu CH, Chen RY. [Determination of nine triterpenoid acids from Ganoderma lucidum of different producting areas by HPLC]. Zhongguo Zhong Yao Za Zhi. 2012 Dec;37(23):3599-603. Chinese. PubMed PMID: 23477148.

6: Zhao J, Chen X, Bi K. [Simultaneous HPLC determination of four triterpenoid acids in Ganoderma lucidum]. Zhongguo Zhong Yao Za Zhi. 2009 Sep;34(17):2220-2. Chinese. PubMed PMID: 19943490.

7: Wang F, Liu JK. Highly oxygenated lanostane triterpenoids from the fungus Ganoderma applanatum. Chem Pharm Bull (Tokyo). 2008 Jul;56(7):1035-7. PubMed PMID: 18591828.

8: Rösecke J, König WA. Constituents of various wood-rotting basidiomycetes. Phytochemistry. 2000 Jul;54(6):603-10. PubMed PMID: 10963454.