Tulobuterol Hydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527053

CAS#: 56776-01-3

Description: Tulobuterol Hydrochloride is a long-acting beta2-adrenergic receptor agonist.

Chemical Structure

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Tulobuterol Hydrochloride
CAS# 56776-01-3
Instruction

Theoretical Analysis

MedKoo Cat#: 527053
Name: Tulobuterol Hydrochloride
CAS#: 56776-01-3
Chemical Formula: C12H19Cl2NO
Exact Mass: 263.08
Molecular Weight: 264.190
Elemental Analysis: C, 54.56; H, 7.25; Cl, 26.84; N, 5.30; O, 6.06

Price and Availability

Size Price Availability Quantity
500mg USD 250 2 Weeks
1g USD 450 2 Weeks
5g USD 950 2 Weeks
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Synonym: Tulobuterol Hydrochloride

IUPAC/Chemical Name: 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol hydrochloride

InChi Key: RSLNRVYIRDVHLY-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H18ClNO.ClH/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13;/h4-7,11,14-15H,8H2,1-3H3;1H

SMILES Code: ClC1=CC=CC=C1C(O)CNC(C)(C)C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 264.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Takizawa Y, Goto T, Sato S, Ohmori N, Mori K, Shimada Y, Chen K, Miyagi T, Fukai F. Skin permeability of tulobuterol in two transdermal formulations and their followability. Drug Discov Ther. 2017 Nov 22;11(5):253-258. doi: 10.5582/ddt.2017.01050. Epub 2017 Oct 11. PubMed PMID: 29021505.

2: Xu J, Xu S, Xiao Y, Chingin K, Lu H, Yan R, Chen H. Quantitative Determination of Bulk Molecular Concentrations of β-Agonists in Pork Tissue Samples by Direct Internal Extractive Electrospray Ionization-Mass Spectrometry. Anal Chem. 2017 Nov 7;89(21):11252-11258. doi: 10.1021/acs.analchem.7b00517. Epub 2017 Oct 26. PubMed PMID: 28988472.

3: Ogasawara T, Sakata J, Aoshima Y, Tanaka K, Yano T, Kasamatsu N. Bronchodilator Effect of Tiotropium via Respimat(®)Administered with a Spacer in Patients with Chronic Obstructive Pulmonary Disease (COPD). Intern Med. 2017 Sep 15;56(18):2401-2406. doi: 10.2169/internalmedicine.8255-16. Epub 2017 Aug 21. PubMed PMID: 28824055; PubMed Central PMCID: PMC5643165.

4: Yao Y, Song P, Wen X, Deng M, Wang J, Guo X. Chiral separation of 12 pairs of enantiomers by capillary electrophoresis using heptakis-(2,3-diacetyl-6-sulfato)-β-cyclodextrin as the chiral selector and the elucidation of the chiral recognition mechanism by computational methods. J Sep Sci. 2017 Jul;40(14):2999-3007. doi: 10.1002/jssc.201700137. PubMed PMID: 28544353.

5: Zeng K, Wang J, Sun Z, Li Q, Liao S, Zhao X, Zheng X. Rapid analysis of interaction between six drugs and β(2) -adrenergic receptor by injection amount-dependent method. Biomed Chromatogr. 2017 Jun;31(6). doi: 10.1002/bmc.3897. Epub 2017 Jan 10. PubMed PMID: 27859454.

6: Inoue H, Niimi A, Matsumoto H, Ito I, Oguma T, Otsuka K, Takeda T, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Mishima M. A 12-week, randomized, parallel-group, proof-of-concept study of tulobuterol patch and salmeterol inhaler as add-on therapy in adult-onset mild-to-moderate asthma. Clin Exp Pharmacol Physiol. 2017 Jan;44(1):21-29. doi: 10.1111/1440-1681.12683. PubMed PMID: 27718262.

7: Yano T, Yonaha T, Hidaka K, Nagahama M, Koshida T, Matsuoka H, Taniguchi M, Tsuneyoshi I. A case of severe acute exacerbation of Yokkaichi asthma treated with a vibrating mesh nebulizer. Respir Med Case Rep. 2016 Aug 3;19:83-5. doi: 10.1016/j.rmcr.2016.08.002. eCollection 2016. PubMed PMID: 27547723; PubMed Central PMCID: PMC4982920.

8: Kubota K, Shibata A, Yamaguchi T. The molecular assembly of the ionic liquid/aliphatic carboxylic acid/aliphatic amine as effective and safety transdermal permeation enhancers. Eur J Pharm Sci. 2016 Apr 30;86:75-83. doi: 10.1016/j.ejps.2016.03.002. Epub 2016 Mar 8. PubMed PMID: 26965004.

9: Liu Y, Deng M, Yu J, Jiang Z, Guo X. Capillary electrophoretic enantioseparation of basic drugs using a new single-isomer cyclodextrin derivative and theoretical study of the chiral recognition mechanism. J Sep Sci. 2016 May;39(9):1766-75. doi: 10.1002/jssc.201501026. Epub 2016 Apr 5. PubMed PMID: 26935589.

10: Kim JH, Kim TH, Park HJ, Choi YJ, Kang JH, Song KH, Koo TS, Seo KW. The pharmacokinetics of the β2-adrenoceptor agonist, tulobuterol, in Beagle dogs following transdermal and intravenous administration. Vet J. 2016 Feb;208:90-2. doi: 10.1016/j.tvjl.2015.10.012. Epub 2015 Oct 13. PubMed PMID: 26639828.

11: Han X, Liu R, Ji L, Hui M, Li Q, Fang L, Bi K. Determination of tulobuterol in rat plasma using a liquid chromatography-tandem mass spectrometry method and its application to a pharmacokinetic study of tulobuterol patch. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:108-114. doi: 10.1016/j.jchromb.2015.11.017. Epub 2015 Nov 28. PubMed PMID: 26638035.

12: Li T, Cao J, Li Z, Wang X, He P. Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search. Food Chem. 2016 Feb 1;192:188-96. doi: 10.1016/j.foodchem.2015.06.104. Epub 2015 Jun 30. PubMed PMID: 26304337.

13: Li Q, Wang J, Zheng YY, Yang L, Zhang Y, Bian L, Zheng J, Li Z, Zhao X, Zhang Y. Comparison of zonal elution and nonlinear chromatography in determination of the interaction between seven drugs and immobilised β(2)-adrenoceptor. J Chromatogr A. 2015 Jul 3;1401:75-83. doi: 10.1016/j.chroma.2015.05.012. Epub 2015 May 14. PubMed PMID: 26002106.

14: Ichikawa M, Kodama Y, Yoshimi K, Shiota S, Kotajima M, Nakajyo M, Seyama K, Fukuchi Y, Takahashi K. Effects of transdermal tulobuterol on dyspnea and respiratory function during exercise in patients with chronic obstructive pulmonary disease. J Thorac Dis. 2015 Apr;7(4):687-96. doi: 10.3978/j.issn.2072-1439.2015.04.22. PubMed PMID: 25973235; PubMed Central PMCID: PMC4419310.

15: Xiong L, Gao YQ, Li WH, Yang XL, Shimo SP. Simple and sensitive monitoring of β2-agonist residues in meat by liquid chromatography-tandem mass spectrometry using a QuEChERS with preconcentration as the sample treatment. Meat Sci. 2015 Jul;105:96-107. doi: 10.1016/j.meatsci.2015.03.013. Epub 2015 Mar 20. PubMed PMID: 25828164.

16: Zheng L, Wu Y, Zhao Y, Li L, Ma Y. [Simultaneous determination of 18 β-agonist residues in feed using QuEChERS sample preparation and high performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2014 Aug;32(8):867-73. Chinese. PubMed PMID: 25434124.

17: Nakai N, Sugiura K, Akiyama M, Katoh N. Acute generalized exanthematous pustulosis caused by dihydrocodeine phosphate in a patient with psoriasis vulgaris and a heterozygous IL36RN mutation. JAMA Dermatol. 2015 Mar;151(3):311-5. doi: 10.1001/jamadermatol.2014.3002. PubMed PMID: 25409173.

18: Wu K, Guo L, Xu W, Xu H, Aguilar ZP, Xu G, Lai W, Xiong Y, Wan Y. Sulfonated polystyrene magnetic nanobeads coupled with immunochromatographic strip for clenbuterol determination in pork muscle. Talanta. 2014 Nov;129:431-7. doi: 10.1016/j.talanta.2014.06.007. Epub 2014 Jun 14. PubMed PMID: 25127616.

19: Tao Y, Zhu F, Chen D, Xie S, Yuanhu P, Wang X, Liu Z, Peng D, Yuan Z. Evaluation of matrix solid-phase dispersion extraction for 11 β-agonists in swine feed by liquid chromatography with electrospray ionization tandem mass spectrometry. J Sep Sci. 2014 Sep;37(18):2574-82. doi: 10.1002/jssc.201400402. Epub 2014 Aug 1. PubMed PMID: 24981594.

20: Pan S, Zhou L, Zhao Y, Chen X, Li X, Jin M. Development and validation of a sensitive method for simultaneous determination of eight β₂-agonists in pork by ultrasonic-assisted extraction and liquid chromatography/tandem mass spectrometry. J Chromatogr Sci. 2015 Jan;53(1):104-11. doi: 10.1093/chromsci/bmu026. Epub 2014 Apr 25. PubMed PMID: 24771052.