WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561713

CAS#: 147859-80-1

Description: Ca-074Me is a selective and cell-permeable inhibitor of cathepsin B.

Price and Availability




Ca-074Me is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 561713
Name: Ca-074Me
CAS#: 147859-80-1
Chemical Formula: C19H30N2O6
Exact Mass: 382.2104
Molecular Weight: 382.45
Elemental Analysis: C, 59.67; H, 7.91; N, 7.32; O, 25.10

Synonym: Ca-074Me; Ca-074Me; Ca-074Me;

IUPAC/Chemical Name: N-(L-3-trans-Propylcarbonyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester


InChi Code: InChI=1S/C19H30N2O6/c1-5-8-13(22)15-16(27-15)17(23)20-14(11(3)6-2)18(24)21-10-7-9-12(21)19(25)26-4/h11-12,14-16H,5-10H2,1-4H3,(H,20,23)/t11-,12-,14-,15+,16-/m0/s1

SMILES Code: O=C(OC)[C@H]1N(C([C@H]([C@@H](C)CC)NC([C@H]2O[C@@H]2C(CCC)=O)=O)=O)CCC1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


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8: Xu Y, Wang J, Song X, Wei R, He F, Peng G, Luo B. Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats. Brain Res Bull. 2016 Jan;120:97-105. doi: 10.1016/j.brainresbull.2015.11.007. Epub 2015 Nov 10. PubMed PMID: 26562519.

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16: Patel N, Nizami S, Song L, Mikami M, Hsu A, Hickernell T, Chandhanayingyong C, Rho S, Compton JT, Caldwell JM, Kaiser PB, Bai H, Lee HG, Fischer CR, Lee FY. CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways. J Orthop Res. 2015 Oct;33(10):1474-86. doi: 10.1002/jor.22795. Epub 2015 Aug 20. PubMed PMID: 25428830.

17: Zhang L, Fu XH, Yu Y, Shui RH, Li C, Zeng HY, Qiao YL, Ni LY, Wang Q. Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis. Lab Invest. 2015 Jan;95(1):65-77. doi: 10.1038/labinvest.2014.135. Epub 2014 Nov 10. PubMed PMID: 25384123.

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