Glipentide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561693

CAS#: 32797-92-5

Description: Glipentide is a second-generation sulfonylurea. It promotes the accumulation of fructose 2,6-bisphosphate in hepatocytes.


Chemical Structure

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Glipentide
CAS# 32797-92-5

Theoretical Analysis

MedKoo Cat#: 561693
Name: Glipentide
CAS#: 32797-92-5
Chemical Formula: C22H27N3O5S
Exact Mass: 445.17
Molecular Weight: 445.530
Elemental Analysis: C, 59.31; H, 6.11; N, 9.43; O, 17.95; S, 7.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Glipentide; Glisentide; Staticum; UR-661; UR 661; UR661;

IUPAC/Chemical Name: N-[2-[4-(Cyclopentylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide

InChi Key: NSJYMFYVNWVGON-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H27N3O5S/c1-30-20-9-5-4-8-19(20)21(26)23-15-14-16-10-12-18(13-11-16)31(28,29)25-22(27)24-17-6-2-3-7-17/h4-5,8-13,17H,2-3,6-7,14-15H2,1H3,(H,23,26)(H2,24,25,27)

SMILES Code: O=C(NCCC1=CC=C(S(=O)(NC(NC2CCCC2)=O)=O)C=C1)C3=CC=CC=C3OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 445.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Watanuki Y, Wanless S, Harris M, Lovvorn JR, Miyazaki M, Tanaka H, Sato K. Swim speeds and stroke patterns in wing-propelled divers: a comparison among alcids and a penguin. J Exp Biol. 2006 Apr;209(Pt 7):1217-30. PubMed PMID: 16547294.

2: Mura P, Cirri M, Faucci MT, Ginès-Dorado JM, Bettinetti GP. Investigation of the effects of grinding and co-grinding on physicochemical properties of glisentide. J Pharm Biomed Anal. 2002 Sep 5;30(2):227-37. PubMed PMID: 12191707.

3: Zornoza A, de Nó C, Martín C, Goñi MM, Martínez Ohárriz MC, Vélaz I. Evidence for polymorphism in glisentide. Int J Pharm. 1999 Sep 20;186(2):199-204. PubMed PMID: 10486438.

4: Mis R, Ramis J, Conte L, Forn J. In-vitro protein binding interaction between a metabolite of triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid and other drugs. J Pharm Pharmacol. 1992 Nov;44(11):935-7. PubMed PMID: 1361542.

5: López-Alarcón L, Berbil-Bautista PR, Guijarro C, Felíu JE. Glipentide and glucose metabolism in isolated rat hepatocytes. Biochem Pharmacol. 1988 Aug 15;37(16):3177-82. PubMed PMID: 2969730.

6: Gómez PL, Planas JM, Moretó M, Bolufer J. Effect of glipentide on galactose absorption and disaccharidase activity in rat small intestine. Rev Esp Fisiol. 1980 Dec;36(4):445-8. PubMed PMID: 7221166.

7: Chanal JL, Calmette MT, Khiat M, Rimbau V, Vera A. Pharmacokinetics and metabolism of 14C-glipentide, a new antidiabetic, after oral and intravenous administration. Arzneimittelforschung. 1977;27(4):852-6. PubMed PMID: 577463.

8: Moncada Lorenzo E, Garcia RV, Barberia Layana JJ, Morant Ciscard JA, Calleja Canelas A. Clinical comparison between glipentide (Staticum) and glibenclamide in diabetics. Curr Ther Res Clin Exp. 1977 Jan;21(1):50-7. PubMed PMID: 401712.

9: Rimbau Barreras V, Uriach Marsal J, Pou Torelló JM. [Pharmacokinetic of glipentide (UR-661) by IV. administration on healthy and diabetic volunteers (author's transl)]. Arch Farmacol Toxicol. 1976 Aug;2(2):115-22. Spanish. PubMed PMID: 791156.

10: Herrera E. Effects of sulfonylureas (tolbutamide, glipentide and glibenclamide) on in vitro glycerol metabolism in adipose tissue from rats. Life Sci. 1975 Feb 15;16(4):645-50. PubMed PMID: 1123965.

11: Sánchez-Casals MS, Morell-Mestre J. [Inotropic effect of tolbutamide and glipentide in isolated guinea pig atria (author's transl)]. Rev Esp Fisiol. 1974 Dec;30(4):273-6. Spanish. PubMed PMID: 4456482.

12: HOPKINS BJ, BAXTER RC, TUTTLE LW. THE RETENTION OF STRONTIUM-90 BY FETAL AND NEWBORN RATS. UR-661. UR Rep. 1965 Mar 29;51:1-14. PubMed PMID: 14291904.

13: BENSON RC, INMAN VT. Brachialgia statica dysesthetica in pregnancy. West J Surg Obstet Gynecol. 1956 Mar;64(3):115-29; discussion, 129-30. PubMed PMID: 13299941.