BMS-813160
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407861

CAS#: 1286279-29-5

Description: BMS-813160 is a potent and selective CCR2/CCR5 antagonist with potential immunomodulating and antineoplastic activities. BMS-813160 specifically binds and prevents the activation of both CCR2 and CCR5. This inhibits the activation of CCR2/CCR5-mediated signal transduction pathways and may inhibit inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion.


Price and Availability

Size
Price

200mg
USD 2650
2g
USD 7950
Size
Price

500mg
USD 3650
5g
Ask price
Size
Price

1g
USD 4950

BMS-813160, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 407861
Name: BMS-813160
CAS#: 1286279-29-5
Chemical Formula: C25H40N8O2
Exact Mass: 484.3274
Molecular Weight: 484.649
Elemental Analysis: C, 61.96; H, 8.32; N, 23.12; O, 6.60


Synonym: BMS-813160; BMS813160; BMS 813160;

IUPAC/Chemical Name: N-[(1R,2S,5R)-5-[(1,1-Dimethylethyl)amino]-2-[(3S)-3-[[7-(1,1-dimethylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]-2-oxo-1-pyrrolidinyl]cyclohexyl]acetamide

InChi Key: CMVHFGNTABZQJU-HCXYKTFWSA-N

InChi Code: InChI=1S/C25H40N8O2/c1-15(34)28-18-12-16(30-25(5,6)7)8-9-19(18)32-11-10-17(22(32)35)29-23-27-14-26-21-13-20(24(2,3)4)31-33(21)23/h13-14,16-19,30H,8-12H2,1-7H3,(H,28,34)(H,26,27,29)/t16-,17+,18-,19+/m1/s1

SMILES Code: CC(N[C@H]1[C@@H](N2C([C@@H](NC3=NC=NC4=CC(C(C)(C)C)=NN43)CC2)=O)CC[C@@H](NC(C)(C)C)C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

The G-protein coupled chemokine receptors CCR2 and CCR5 are expressed on the surface of monocytes and macrophages, and stimulate their migration and infiltration; they play key roles in inflammation and autoimmune disease. CCR2 and CCR5 are overexpressed in certain cancer cell types, and are also involved in angiogenesis, and in tumor cell migration, proliferation and metastasis.


References

1: Norman P. A dual CCR2/CCR5 chemokine antagonist, BMS-813160? Evaluation of
WO2011046916. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24. doi:
10.1517/13543776.2011.622750. Epub 2011 Sep 22. Review. PubMed PMID: 21936726.