BTT-3033
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MedKoo CAT#: 555105

CAS#: 1259028-99-3

Description: BTT-3033 is a α2β1 integrin inhibitor. BTT-3033 blocks platelet attachment under flow (90 dynes/cm(2)). The action of BTT-3033, unlike that of BTT-3034, was dependent on Tyr-285.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 450 2 Weeks
50mg USD 1350 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-04-07. Prices are subject to change without notice.

BTT-3033, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555105
Name: BTT-3033
CAS#: 1259028-99-3
Chemical Formula: C23H20FN5O3S
Exact Mass: 465.1271
Molecular Weight: 465.5034
Elemental Analysis: C, 59.35; H, 4.33; F, 4.08; N, 15.05; O, 10.31; S, 6.89


Synonym: BTT-3033; BTT 3033; BTT3033.

IUPAC/Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-(4-(3-phenylureido)phenyl)-1H-pyrazole-4-sulfonamide

InChi Key: NSLIQOPYDUKWTA-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20FN5O3S/c1-28(33(31,32)22-15-25-29(16-22)21-11-7-17(24)8-12-21)20-13-9-19(10-14-20)27-23(30)26-18-5-3-2-4-6-18/h2-16H,1H3,(H2,26,27,30)

SMILES Code: O=S(C1=CN(C2=CC=C(F)C=C2)N=C1)(N(C)C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

The interaction between α2β1 integrin (GPIa/IIa, VLA-2) and vascular collagen is one of the initiating events in thrombus formatio


References

1: Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K,
Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J. Novel α2β1 integrin
inhibitors reveal that integrin binding to collagen under shear stress conditions
does not require receptor preactivation. J Biol Chem. 2012 Dec
28;287(53):44694-702. doi: 10.1074/jbc.M111.309450. Epub 2012 Nov 6. PubMed PMID:
23132859; PubMed Central PMCID: PMC3531784.