Quinine sulfate dihydrate | CAS#6119-70-6 (sulfate dihydrate) | antimalarial agent

Quinine sulfate dihydrate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561647

CAS#: 6119-70-6 (sulfate dihydrate)

Description: Quinine sulfate dihydrate is an antimalarial agent. It works by reducing oxygen intake and carbohydrate metabolism, disrupting DNA replication and transcription via DNA intercalation, and reducing excitability of muscle fibers via alteration of calcium distribution. It is also an inhibitor of P-glycoprotein.

Chemical Structure

Quinine sulfate dihydrate

CAS# 6119-70-6 (sulfate dihydrate)

Instruction

Theoretical Analysis

MedKoo Cat#: 561647
Name: Quinine sulfate dihydrate
CAS#: 6119-70-6 (sulfate dihydrate)
Chemical Formula: C20H28N2O7S
Exact Mass: 0.00
Molecular Weight: 440.510
Elemental Analysis: C, 54.53; H, 6.41; N, 6.36; O, 25.42; S, 7.28

Price and Availability

Size	Price	Availability
10g	USD 185	2 weeks
50g	USD 340	2 weeks
250g	USD 820	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Quinine sulfate dihydrate; Chinini sulfas; Quinine hemisulfate salt monohydrate;

IUPAC/Chemical Name: (1R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol hemisulfate hydrate

InChi Key: ZYCWGZVLCXRARB-HZQSTTLBSA-N

InChi Code: InChI=1S/C20H24N2O2.H2O4S.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);1H2/t13-,14-,19-,20+;;/m0../s1

SMILES Code: O[C@@H]([C@H]1N(CC2)C[C@H](C=C)[C@]2([H])C1)C3=CC=NC4=CC=C(OC)C=C34.O=S(O)(O)=O.O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 440.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Würth C, Grabolle M, Pauli J, Spieles M, Resch-Genger U. Comparison of methods and achievable uncertainties for the relative and absolute measurement of photoluminescence quantum yields. Anal Chem. 2011 May 1;83(9):3431-9. doi: 10.1021/ac2000303. Epub 2011 Apr 7. PubMed PMID: 21473570.

2: Würth C, Lochmann C, Spieles M, Pauli J, Hoffmann K, Schüttrigkeit T, Franzl T, Resch-Genger U. Evaluation of a commercial integrating sphere setup for the determination of absolute photoluminescence quantum yields of dilute dye solutions. Appl Spectrosc. 2010 Jul;64(7):733-41. doi: 10.1366/000370210791666390. PubMed PMID: 20615286.

3: Mangwala Kimpende P, Van Meervelt L. Redetermination of bis-{(1S,2S,4S,5R)-2-[(R)-hy-droxy(6-meth-oxy-4-quinol-yl)meth-yl]-5-vinyl-quinuc lidinium} sulfate dihydrate. Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 28;66(Pt 9):o2443-4. doi: 10.1107/S1600536810034288. PubMed PMID: 21588765; PubMed Central PMCID: PMC3008057.

4: Fluorescence standard reference material: quinine sulfate dihydrate. Appl Opt. 1981 May 1;20(9):1718. PubMed PMID: 20309374.

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Quinine sulfate dihydrate featured