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MedKoo CAT#: 584158

CAS#: 2156-27-6

Description: Benproperine is a bioactive molecule that has antineoplastic properties.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-15. Prices are subject to change without notice.

Benproperine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 584158
Name: Benproperine
CAS#: 2156-27-6
Chemical Formula: C21H27NO
Exact Mass: 309.2093
Molecular Weight: 309.45
Elemental Analysis: C, 81.51; H, 8.79; N, 4.53; O, 5.17

Synonym: Benproperine; Bemproperina; Benproperinum; Pirexyl; BRN 1258822; BRN-1258822; BRN1258822

IUPAC/Chemical Name: 1-(2-(2-Benzylphenoxy)-1-methylethyl)piperidine


InChi Code: InChI=1S/C21H27NO/c1-18(22-14-8-3-9-15-22)17-23-21-13-7-6-12-20(21)16-19-10-4-2-5-11-19/h2,4-7,10-13,18H,3,8-9,14-17H2,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Feng S, Liu J, Han X, Fan J. Resonance light scattering study on the interaction of benproperine phosphate with eriochrome blue black R in the presence of sodium dodecylbenzene sulphonate and its analytical application. Luminescence. 2009 Mar-Apr;24(2):67-72. doi: 10.1002/bio.1064. PubMed PMID: 18800357.

2: Li Y, Zhong DF, Chen SW, Maeba I. Identification of some benproperine metabolites in humans and investigation of their antitussive effect. Acta Pharmacol Sin. 2005 Dec;26(12):1519-26. PubMed PMID: 16297353.

3: Li Y, Sun Y, Dong Y, Zhang Y, Zhong D. Identification and quantitative determination of benproperine metabolites in human plasma and urine by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 2;830(1):71-80. Epub 2005 Nov 8. PubMed PMID: 16280263.

4: Chen S, Min L, Li Y, Li W, Zhong D, Kong W. Anti-tussive activity of benproperine enantiomers on citric-acid-induced cough in conscious guinea-pigs. J Pharm Pharmacol. 2004 Feb;56(2):277-80. PubMed PMID: 15005888.

5: Du ZM, Huang HH, Chen XY, Zhong DF. [Study on hydroxylated metabolites of benproperine in human urine]. Yao Xue Xue Bao. 2000 Dec;35(12):916-20. Chinese. PubMed PMID: 12567915.

6: Du ZM, Zhong DF, Kang Y, Chen XY. [Enantioselective pharmacokinetics of benproperine in healthy volunteers]. Yao Xue Xue Bao. 2000 Dec;35(12):909-12. Chinese. PubMed PMID: 12567913.

7: Yang XJ, Yang XY. [Determination of benproperine phosphate tablets by high performance liquid chromatography]. Se Pu. 2000 Nov;18(6):566-7. Chinese. PubMed PMID: 12541753.