Zilpaterol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526442

CAS#: 119520-05-7

Description: Zilpaterol is a growth promotant, acting as a ß-AR (ß-Adrenergic) agonist.


Chemical Structure

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Zilpaterol
CAS# 119520-05-7

Theoretical Analysis

MedKoo Cat#: 526442
Name: Zilpaterol
CAS#: 119520-05-7
Chemical Formula: C14H19N3O2
Exact Mass: 261.15
Molecular Weight: 261.32
Elemental Analysis: C, 64.35; H, 7.33; N, 16.08; O, 12.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Zilpaterol

IUPAC/Chemical Name: 4,5,6,7-Tetrahydro-7-hydroxy-6-(isopropylamino)-imidazo[4,5,1-jk]-[1]benzazepin-2(1H)-one

InChi Key: ZSTCZWJCLIRCOJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H19N3O2/c1-8(2)15-11-6-7-17-12-9(13(11)18)4-3-5-10(12)16-14(17)19/h3-5,8,11,13,15,18H,6-7H2,1-2H3,(H,16,19)

SMILES Code: O=C1NC2=C(N1CCC(NC(C)C)C3O)C3=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 261.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wells JE, Berry ED, Kim M, Shackelford SD, Hales KE. Evaluation of Commercial β-Agonists, Dietary Protein, and Shade on Fecal Shedding of Escherichia coli O157:H7 from Feedlot Cattle. Foodborne Pathog Dis. 2017 Nov;14(11):649-655. doi: 10.1089/fpd.2017.2313. Epub 2017 Aug 28. PubMed PMID: 28846460.

2: Hales KE, Foote AP, Brake DW, Brown-Brandl TM, Artegoitia VM, Freetly HC. Effects of zilpaterol hydrochloride on methane production, total body oxygen consumption, and blood metabolites in finishing beef steers. J Anim Sci. 2017 Jul;95(7):3192-3197. doi: 10.2527/jas.2017.1527. PubMed PMID: 28727087.

3: Antonelo DS, Mazon MR, Nubiato KEZ, Gómez JFM, Brigida DJ, Gomes RC, Netto AS, Leme PR, Silva SL. Effects of immunocastration and β-adrenergic agonists on the performance and carcass traits of feedlot finished Nellore cattle. Animal. 2017 Nov;11(11):2103-2110. doi: 10.1017/S1751731117000842. Epub 2017 Apr 26. PubMed PMID: 28443535.

4: Cadaret CN, Beede KA, Riley HE, Yates DT. Acute exposure of primary rat soleus muscle to zilpaterol HCl (β2 adrenergic agonist), TNFα, or IL-6 in culture increases glucose oxidation rates independent of the impact on insulin signaling or glucose uptake. Cytokine. 2017 Aug;96:107-113. doi: 10.1016/j.cyto.2017.03.014. Epub 2017 Apr 5. PubMed PMID: 28390265; PubMed Central PMCID: PMC5483180.

5: May ND, McEvers TJ, Walter LJ, Reed JA, Hutcheson JP, Lawrence TE. Fabrication yields of serially harvested calf-fed Holstein steers fed zilpaterol hydrochloride. J Anim Sci. 2017 Mar;95(3):1209-1218. doi: 10.2527/jas.2016.1246. PubMed PMID: 28380524.

6: Hagenmaier JA, Reinhardt CD, Bartle SJ, Thomson DU. Effect of shade on animal welfare, growth performance, and carcass characteristics in large pens of beef cattle fed a beta agonist in a commercial feedlot. J Anim Sci. 2016 Dec;94(12):5064-5076. doi: 10.2527/jas.2016-0935. PubMed PMID: 28046169.

7: May ND, McEvers TJ, Walter LJ, Reed JA, Hutcheson JP, Lawrence TE. Carcass grading characteristics of serially harvested calf-fed Holstein steers fed zilpaterol hydrochloride. J Anim Sci. 2016 Dec;94(12):5129-5136. doi: 10.2527/jas.2016-0837. PubMed PMID: 28046164.

8: Samuelson KL, Hubbert ME, Löest CA. Effects of dietary urea concentration and zilpaterol hydrochloride on performance and carcass characteristics of finishing steers. J Anim Sci. 2016 Dec;94(12):5350-5358. doi: 10.2527/jas.2016-0875. PubMed PMID: 28046136.

9: May ND, McEvers TJ, Walter LJ, Reed JA, Hutcheson JP, Lawrence TE. Byproduct yields of serially harvested calf-fed Holstein steers fed zilpaterol hydrochloride. J Anim Sci. 2016 Sep;94(9):4006-4015. doi: 10.2527/jas.2016-0486. PubMed PMID: 27898897.

10: Walter LJ, Cole NA, Jennings JS, Hutcheson JP, Meyer BE, Schmitz AN, Reed DD, Lawrence TE. The effect of zilpaterol hydrochloride supplementation on energy metabolism and nitrogen and carbon retention of steers fed at maintenance and fasting intake levels. J Anim Sci. 2016 Oct;94(10):4401-4414. doi: 10.2527/jas.2016-0612. PubMed PMID: 27898856.

11: Moholisa E, Hugo A, Strydom PE, van Heerden I. The effects of animal age, feeding regime and a dietary beta-agonist on tenderness of three beef muscles. J Sci Food Agric. 2017 Jun;97(8):2375-2381. doi: 10.1002/jsfa.8049. Epub 2016 Nov 14. PubMed PMID: 27716945.

12: Cheng TD, Shelver WL, Hong CC, McCann SE, Davis W, Zhang Y, Ambrosone CB, Smith DJ. Urinary Excretion of the β-Adrenergic Feed Additives Ractopamine and Zilpaterol in Breast and Lung Cancer Patients. J Agric Food Chem. 2016 Oct 12;64(40):7632-7639. Epub 2016 Sep 27. PubMed PMID: 27641640; PubMed Central PMCID: PMC5510757.

13: Frese DA, Reinhardt CD, Bartle SJ, Rethorst DN, Bawa B, Thomason JD, Loneragan GH, Thomson DU. Effect of ractopamine hydrochloride and zilpaterol hydrochloride on cardiac electrophysiologic and hematologic variables in finishing steers. J Am Vet Med Assoc. 2016 Sep 15;249(6):668-77. doi: 10.2460/javma.249.6.668. PubMed PMID: 27585105.

14: World Health Organization. Evaluation of certain veterinary drug residues in food. Eighty-first report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organ Tech Rep Ser. 2016;(997):1-110. PubMed PMID: 27509597.

15: Avendaño-Reyes L, Meraz-Murillo FJ, Pérez-Linares C, Figueroa-Saavedra F, Correa A, Álvarez-Valenzuela FD, Guerra-Liera JE, López-Rincón G, Macías-Cruz U. Evaluation of the efficacy of Grofactor, a beta-adrenergic agonist based on zilpaterol hydrochloride, using feedlot finishing bulls. J Anim Sci. 2016 Jul;94(7):2954-61. doi: 10.2527/jas.2015-9878. PubMed PMID: 27482682.

16: Hales KE, Foote AP, Jones SA, Shackelford SD, Boyd BM, Erickson GE. The effects of zilpaterol hydrochloride and shade on blood metabolites of finishing beef steers. J Anim Sci. 2016 Jul;94(7):2937-41. doi: 10.2527/jas.2015-9967. PubMed PMID: 27482680.

17: Buntyn JO, Burdick Sanchez NC, Schmidt TB, Erickson GE, Sieren SE, Jones SJ, Carroll JA. The metabolic, stress axis, and hematology response of zilpaterol hydrochloride supplemented beef heifers when exposed to a dual corticotropin-releasing hormone and vasopressin challenge. J Anim Sci. 2016 Jul;94(7):2798-810. doi: 10.2527/jas.2015-0192. PubMed PMID: 27482667.

18: Cônsolo NR, Ferrari VB, Mesquita LG, Goulart RS, Silva LF. Zilpaterol hydrochloride improves beef yield, changes palatability traits, and increases calpain-calpastatin gene expression in Nellore heifers. Meat Sci. 2016 Nov;121:375-81. doi: 10.1016/j.meatsci.2016.07.005. Epub 2016 Jul 11. PubMed PMID: 27427783.

19: Knobel-Graves SM, Brooks JC, Johnson BJ, Starkey JD, Beckett JL, Hodgen JM, Hutcheson JP, Streeter MN, Thomas CL, Rathmann RJ, Garmyn AJ, Miller MF. Effect of vitamin D, zilpaterol hydrochloride supplementation, and postmortem aging on shear force measurements of three muscles in finishing beef steers. J Anim Sci. 2016 Jun;94(6):2637-47. doi: 10.2527/jas.2015-0121. PubMed PMID: 27285939.

20: Walter LA, McEvers TJ, May ND, Reed JA, Hutcheson JP, Lawrence TE. The effect of days on feed and zilpaterol hydrochloride supplementation on feeding behavior and live growth performance of Holstein steers. J Anim Sci. 2016 May;94(5):2139-50. doi: 10.2527/jas.2015-0012. PubMed PMID: 27285710.