Benarthin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584146

CAS#: 143651-45-0

Description: Benarthin is an inhibitor of pyroglutamyl peptidase (PG-peptidase).


Price and Availability

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Benarthin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584146
Name: Benarthin
CAS#: 143651-45-0
Chemical Formula: C17H25N5O7
Exact Mass: 411.1754
Molecular Weight: 411.41
Elemental Analysis: C, 49.63; H, 6.13; N, 17.02; O, 27.22


Synonym: Benarthin

IUPAC/Chemical Name: L-Threonine, N-(N(sup 2)-(2,3-dihydroxybenzoyl)-L-arginyl)-

InChi Key: RYFDAFYFFUVLNW-QRTLGDNMSA-N

InChi Code: InChI=1S/C17H25N5O7/c1-8(23)12(16(28)29)22-15(27)10(5-3-7-20-17(18)19)21-14(26)9-4-2-6-11(24)13(9)25/h2,4,6,8,10,12,23-25H,3,5,7H2,1H3,(H,21,26)(H,22,27)(H,28,29)(H4,18,19,20)/t8-,10+,12+/m1/s1

SMILES Code: C[C@@H](O)[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC(C1=CC=CC(O)=C1O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Hatsu M, Tuda M, Muraoka Y, Aoyagi T, Takeuchi T. Benarthin: a new inhibitor of pyroglutamyl peptidase. III. Synthesis and structure-activity relationships. J Antibiot (Tokyo). 1992 Jul;45(7):1088-95. PubMed PMID: 1355473.

2: Hatsu M, Naganawa H, Aoyagi T, Takeuchi T. Benarthin: a new inhibitor of pyroglutamyl peptidase. II. Physico-chemical properties and structure determination. J Antibiot (Tokyo). 1992 Jul;45(7):1084-7. PubMed PMID: 1355472.

3: Aoyagi T, Hatsu M, Kojima F, Hayashi C, Hamada M, Takeuchi T. Benarthin: a new inhibitor of pyroglutamyl peptidase. I. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 1992 Jul;45(7):1079-83. Erratum in: J Antibiot (Tokyo) 1992 Oct;45(10):C5. PubMed PMID: 1355471.