Bemegride
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584144

CAS#: 64-65-3

Description: Bemegride is a central nervous system stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-19. Prices are subject to change without notice.

Bemegride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 584144
Name: Bemegride
CAS#: 64-65-3
Chemical Formula: C8H13NO2
Exact Mass: 155.0946
Molecular Weight: 155.19
Elemental Analysis: C, 61.91; H, 8.44; N, 9.03; O, 20.62


Synonym: Bemegride; Antibarbi; Agipnon; Ahypnon; Eukraton; Malysol; Mikedimide; Zentraleptin

IUPAC/Chemical Name: 2,6-Piperidinedione, 4-ethyl-4-methyl-

InChi Key: ORRZGUBHBVWWOP-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)

SMILES Code: O=C(CC(C)(CC)C1)NC1=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Katagai H, Yasui-Furukori N, Kikuchi A, Kaneko S. Bemegride lengthens seizure duration during electric convulsive therapy in a schizophrenic patient with increased seizure threshold. J ECT. 2009 Mar;25(1):61-3. doi: 10.1097/0b013e3181723725. PubMed PMID: 18955899.

2: Cherchenko AP, Todor IM. [Changes in energy metabolism in the brain of bemegride-kindled rabbits]. Fiziol Zh. 2002;48(1):50-5. Ukrainian. PubMed PMID: 11928632.

3: Jibiki I, Yamaguchi N, Matsuda H, Hisada K. Paradoxical enhancement of hypoperfusion single photon emission CT images in epileptic focus with bemegride activation. Observation from subtraction of 99mTc hexamethyl-propyleneamine oxime brain single photon emission CT images. Eur Neurol. 1992;32(3):146-50. PubMed PMID: 1592071.

4: Soto-Otero R, Mendez-Alvarez E, Sierra-Paredes G, Galan-Valiente J, Aguilar-Veiga E, Sierra-Marcuño G. Reversed-phase high-performance liquid chromatography method for the determination of bemegride in serum and brain tissue: pharmacokinetics and brain distribution of an intraperitoneal subconvulsive dose in rats. J Pharm Biomed Anal. 1991;9(2):177-82. PubMed PMID: 1873309.

5: Kawamura M, Murase K, Yasuhara Y, Mogami H, Tanada S, Hamamoto K, Hatakeyama T, Kimura H, Sakaki S. [Visualization of epileptic lesions using single photon emission computed tomography (SPECT) with N-isopropyl-p-(123I) iodoamphetamine after intravenous loading of bemegride--report of a case]. Nihon Igaku Hoshasen Gakkai Zasshi. 1989 Feb 25;49(2):199-205. Japanese. PubMed PMID: 2787907.

6: Mistry DK, Cottrell GA. Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. Exp Physiol. 1990 Mar;75(2):199-209. PubMed PMID: 2160252.

7: Arblaster CI, Cameron DW, Lavi Y, Laycock GM, Shulman A. The guinea-pig isolated atrium as a model system for the central actions of selected CNS stimulant and depressant drugs. Part 2. Mechanisms involved in the actions and interactions of the convulsant bemegride and its hypnotic homologue 3-methyl-3-n-butylglutarimide. Methods Find Exp Clin Pharmacol. 1988 Mar;10(3):177-211. PubMed PMID: 2455201.

8: Weber M, Huttin B, Gehin P, Vespignani H, Brichet B. [Changes in somatosensory evoked potentials during EEG activation by bemegride in man]. Rev Electroencephalogr Neurophysiol Clin. 1985 Jul;15(1):59-64. French. PubMed PMID: 4048612.

9: Bülau P, Fröscher W. [EEG activation using bemegride in the diagnosis of epilepsy. 2. Catamnestic studies]. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1984 Sep;15(3):132-7. German. PubMed PMID: 6435995.

10: Fröscher W, Bülau P. [EEG activation with bemegride in epilepsy diagnosis. 1: Literature review]. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1984 Jun;15(2):75-81. German. PubMed PMID: 6432516.

11: Scholfield CN. Antagonism of gamma-aminobutyric acid and muscimol by picrotoxin, bicuculline, strychnine, bemegride, leptazol, D-tubocurarine and theophylline in the isolated olfactory cortex. Naunyn Schmiedebergs Arch Pharmacol. 1982 Mar;318(4):274-80. PubMed PMID: 7078662.

12: Faingold CL, Hoffmann WE. Effects of bemegride on the sensory responses of neurons in the hippocampus and brain stem reticular formation. Electroencephalogr Clin Neurophysiol. 1981 Oct;52(4):316-27. PubMed PMID: 6169508.

13: Shearman G, Lal H. Discriminative stimulus properties of pentylenetetrazol and bemegride: some generalization and antagonism tests. Psychopharmacology (Berl). 1979 Sep;64(3):315-9. PubMed PMID: 41279.

14: Micheletti M, Laroye M, Coquillat G, Micheletti G, Kurtz D. [Semiological comparison of spontaneous and bemegride-induced epileptic seizures (author's transl)]. Rev Electroencephalogr Neurophysiol Clin. 1979 Jul-Sep;9(3):241-9. French. PubMed PMID: 523736.

15: Järbe TU. Alcohol-discrimination in gerbils: interactions with bemegride, DH-524, Amphetamine, and delta9-THC. Arch Int Pharmacodyn Ther. 1977 May;227(1):118-29. PubMed PMID: 901060.

16: Järbe TU, Johansson JO. Pentobarbital, diazepam and bemegride: their effects on open-field behavior in the gerbil (Meriones unguiculatus). Arch Int Pharmacodyn Ther. 1977 Jan;225(1):88-97. PubMed PMID: 849067.

17: Buchbauer G. [Phytopharmacological study on proadiphene, amiphenazole and bemegride in association with phenobarbitone (author's transl)]. Arzneimittelforschung. 1977;27(5):976-8. German. PubMed PMID: 577883.

18: Jårbe. Methaqualone discrimination in gerbils: interactions with bemegride and imidazoline (DH-524). Med Biol. 1976 Dec;54(5):364-8. PubMed PMID: 162743.

19: Johansson JO, Järbe TU. Diazepam as a discriminative cue: its antagonism by bemegride. Eur J Pharmacol. 1975 Feb;30(2):372-5. PubMed PMID: 1126370.

20: Aleksandrov AA, Lenkov DN. [The influence of bemegride on frog spinal cord root potentials]. Neirofiziologiia. 1975;7(5):527-31. Russian. PubMed PMID: 1207835.